Core A: Administrative Core

项目摘要-行政核心（核心A） 管理核心（核心A）由HN SPORE PI博士共同领导。Robert Ferris和Heath Skinner以及 在希尔曼癌症中心（HCC）财务和行政人员的支持下， 由HN SPORE和HCC共同支持（见机构承诺书）。主 核心A的职能是满足每个项目和核心的行政和监督需求， 具体负责确保HN SPORE的每个方面都进展到其各自的翻译， 临床或职业提升目标。由于本核心及其相关行政管理的中心地位， 功能，器官特异性数据库（OSD）是一个大型，纵向，前瞻性收集，易于搜索， 临床数据库现在位于Core A。它由HN SPORE直接支持，拥有超过12，000个 个体患者和临床记录。核心A主管还将监督来自OSD的数据请求 由于正在进行的额外“组学”和成像功能的集成， 建议的HN SPORE期间的过程。核心A董事还将监督核心A的工作 临床研究协调员，沿着机构支持，协调HN的临床试验 孢子。核心A联合董事还将促进整个项目、发展 研究项目，职业提升计划获奖者，和核心，确定新的机会， HN SPORE内进行的每项研究方向的潜在变更。总体而言，核心A 领导团队监控支出，协调每月HN SPORE会议，邀请演讲者，至少两次 年度执行委员会会议、内部和外部咨询委员会会议以及Inter-SPORE 会议.核心A也是所有NCI、机构间和机构外交流的主要联络点 并协调多个非机构临床试验。此外，核心A协调研究和奠定 出版物、网站开发、宣传活动、筹资和其他外联工作 （包括我们与约翰霍普金斯、霍华德大学、埃默里和梅哈里学院的外联项目， 增加代表性不足的少数民族在HN SPORE中的参与）。核心A对协调至关重要 的HN SPORE，特别是工作，以确保成功完成HN SPORE的目标，以及 更广泛地说，在HCC培养持续的高影响力翻译研究文化，目标是 改变HNSCC的管理实践。

PROJECT SUMMARY – ADMINISTRATIVE CORE (CORE A) The Administrative Core (Core A) is co-led by HN SPORE PIs Drs. Robert Ferris and Heath Skinner as well as by Dr. Dan Zandberg, with support from the Hillman Cancer Center (HCC) fiscal and administrative staff supported jointly by the HN SPORE and the HCC (see Letter of Institutional Commitment). The primary function of Core A is to serve the administrative and oversight needs of each Project and Core, with the specific responsibility of ensuring each aspect of the HN SPORE is progressing to its individual translational, clinical or career enhancement goal. Due to the centrality of this Core and its associated administrative function, the organ specific database (OSD) a large, longitudinal, prospectively collected, easily searchable, clinical database is now housed in Core A. It is directly supported by the HN SPORE with over 12,000 individual patients and clinical records. The Core A directors will oversee data requests from the OSD as well as the integration of additional ‘’-omics’ and imaging functionality that is ongoing and will be completed over the course of the proposed HN SPORE period. The Core A directors will also oversee the work of the Core A Clinical Research Coordinator who, along with institutional support, coordinates the clinical trials of the HN SPORE. The Core A Co-Directors will also facilitate interactions between full projects, Developmental Research Projects, Career Enhancement Program Awardees, and Cores, identifying new opportunities and potential changes in direction of each study performed within the HN SPORE. Collectively, the Core A leadership team monitor expenditures coordinate monthly HN SPORE meetings, invited speakers, at least bi- annual Executive Committee meetings, Internal and External Advisory Board meetings and Inter-SPORE meetings. Core A is also the primary point of contact for all NCI, inter-and extra-institutional communications and coordinates multi-noninstitutional clinical trials. Additionally, Core A coordinates research and lay publications, website development HNSCC advocacy activities, fund-raising and additional outreach efforts (including our outreach program with Johns Hopkins, Howard University, Emory and Meharry College to increase participation of under-represented minorities in the HN SPORE). Core A is critical to the coordination of the HN SPORE, specifically working to ensure the successful completion of the HN SPORE aims as well as more generally fostering a continued culture of highly impactful translational research at HCC, with a goal of changing practice in the management of HNSCC.