HORNET Center for Autonomic Nerve Recording and Stimulation Systems (CARSS)

植入的导线对于与周围神经系统的直接接口至关重要，并已在临床上使用 从20世纪60年代开始。即便如此，也没有开放架构或开源的引线可用于自主神经。 刺激和记录。这对于测量柔软、小直径的神经来说尤其是一个问题。 1毫米或更小。由于这些都是生物电子医学中非常感兴趣的目标，Nest 4将引入一个新的 基于螺旋袖带格式的开放式神经接口。这款袖口解决了 缩小聚二甲基硅氧烷基袖的传统材料和制造方法的规模 采用不同的方案实现实用的神经袖带，采用复合型对二甲苯C-PDMS结构。 卡司螺旋式微制造袖口使用软聚合物和薄膜电极来实现微型化 袖口外形尺寸。通过对对二甲苯电极的后处理，实现了对旋式螺旋套筒的设计 阵列采用热成型工艺来实现最终的三维形状。螺旋设计是自行设计的 大小调整和自动闭合，无需缝合。手铐伴随着一种微创的， 定制内窥镜工具，将简化手术，并允许进入更深的自主神经分支。 在Nest 4中，将开发对二甲苯螺旋袖套，进行台式测试，并通过外科手术进行演示 放置工具，为临床生物电子医学中更小的神经铺平了道路 研究。

Implanted leads are critical for direct interfaces to the peripheral nervous system and have been used clinically since the 1960s. Even so, no open-architecture or open-source leads are available for autonomic nerve stimulation and recording. This is especially a problem for interfacing with soft, small diameter nerves measuring 1 mm or less. Since these are of great interest as targets in bioelectronic medicine, NEST 4 will introduce a new open-architecture nerve interface based on a helical cuff format. This cuff addresses the limitations of downscaling traditional materials and fabrication methods for polydimethylsiloxane-based cuffs and instead adopts a different scheme to achieve practical nerve cuffs using a composite Parylene C-PDMS structure. The CARSS helical microfabricated cuff uses soft polymers and thin film electrodes to achieve a miniaturized cuff form factor. The contra-rotational helical cuff design is achieved by post-processing the Parylene electrode array using a thermoforming process to achieve the final three-dimensional shape. The helical design is self- sizing and self-closing which avoids the need for sutures. The cuff is accompanied by a minimally invasive, custom endoscopic tool that will simplify surgery and allow access to deeper autonomic nerve branches. In NEST 4, the Parylene helical cuff will be developed, benchtop tested, and demonstrated with the surgical placement tool, paving the way for a widely accessible cuff for smaller nerves in clinical bioelectronic medicine research.