NEW TECHNIQUE FOR QUANTIFYING ATRIAL FIBRILLATION

心房颤动是一种常见的疾病， 显著的发病率和死亡率，包括栓塞性卒中和症状 与心房机械功能丧失和房室 同步性目前治疗房颤的方法包括：药物治疗， 心脏复律（外部和内部），导管消融束 他的，外科迷宫，以及最近，试图创造功能性的 相当于经导管消融术的外科迷宫。 目前，明显缺乏工具来协助临床医生 确定这些治疗策略中哪一种最适合给定的 病人随着新的治疗方法的出现， 继续出现。除了立即需要优化 耐心治疗，有一个更好的了解更长远的需要 负责心房肌电生理机制 纤维性颤动 该项目的目标是开发一种新的度量标准， 量化电传播的时空结构， 心房颤动这些指标，来自心内膜电图， 基于将电描记图数据表示为激活序列 事件而不是一组连续波形。 拟议的商业应用：Creare将开发一种新技术， 评估预期用于以下研究的房颤患者： 心脏电生理实验室该技术将提供 临床医生具有重要的新能力，并具有巨大的商业价值 心脏数据采集系统供应商的兴趣 电生理实验室

Atrial fibrillation is a common disorder and can be associated with significant morbidity and mortality, including embolic stroke and symptoms related to loss of atrial mechanical function and atrioventricular synchrony. Current treatment for atrial fibrillation includes: medication, cardioversion (external and internal), catheter ablation of the bundle of His, surgical maze, and most recently, attempts to create the functional equivalent of surgical maze by transcatheter ablation. At present, there is a clear lack of tools to assist the clinician in determining which of these treatment strategies is best suited for a given patient. This problem is likely to be compounded as new treatments continue to emerge. In addition to the immediate need for optimizing patient treatment, there is a longer-term need for a better understanding of the electrophysiological mechanisms responsible for atrial fibrillation. The goal of this project is development of a new class of metrics for quantifying the spatiotemporal structure of electrical propagation during atrial fibrillation. These metrics, derived from endocardial electrograms, are based on representing the electrogram data as a sequence of activation events rather than a set of continuous waveforms. PROPOSED COMMERCIAL APPLICATIONS: Creare will develop a new technique for evaluating patients with atrial fibrillation intended for use in the cardiac electrophysiology laboratory. The technique will provide the clinician with a significant new capability and be of great commercial interest to vendors of data acquisition systems for use in the cardiac electrophysiology laboratory.