课题基金 / 基金详情

Preclinical Evaluation Of Neutralizing Antibodies Elicit

Preclinical Evaluation Of Neutralizing Antibodies Elicit
中和抗体的临床前评估引发
批准号：
6684230
负责人：
John R Mascola
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6684230
关键词：
AIDS vaccines Rodentias flow cytometry human immunodeficiency virus 1 immunization lymphocyte method development monocyte neutralizing antibody tissue /cell culture vaccine development

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中文摘要
翻译
对抗体介导的病毒中和作用进行精确测量的能力对于评估中和作用机制和评估免疫引起的抗体反应非常重要。对于HIV-1，使用原代病毒分离物和人类靶细胞，如PBMC，是一种体外测定系统，被认为可以测量生理上相关的病毒中和。使用这种方法，筛选和测量候选疫苗产生的临床前抗体反应。
英文摘要
The ability to make accurate and precise measurements of antibody-mediated virus neutralization is important for the evaluation of mechanisms of neutralization and for the assessment of antibody responses elicited by immunization. For HIV-1, the use of primary virus isolates and human target cells, such as PBMC, is an in vitro assay system that is believed to measure physiologically relevant virus neutralization. Using this assay, preclinical antibody responses generated by vaccine candidates were screened and measured.
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