Skin Temperature and Perfusion in Venous Disease

描述（由申请人提供）：静脉性溃疡对超过200万美国人构成严重的健康威胁。 研究患有慢性静脉功能不全（CVI）的个体是至关重要的，这是溃疡的已知罪魁祸首，希望找到预防方法。 本研究的目的是测量皮肤温度和组织灌注的两个下肢的老年人与CVI。 将使用红外线温度计测量踝部以上两条小腿的内侧（最易发生溃疡），以评价皮肤温度，并使用激光多普勒流量计测量组织灌注。 目的是建立规范数据，并描述皮肤温度和组织灌注之间的相关性。 描述性比较研究将比较从各种门诊和社区环境中招募的至少50岁的52名受试者（26名患有CVI，26名未患有CVI）样本的皮肤温度和组织灌注。 将使用ANOVA和相关性分析数据。 这项研究的结果将增加对皮肤温度和组织灌注的小腿皮肤受CVI影响的知识不足的基础。 这些数据将揭示这两个“生命体征”，特别是皮肤温度，是否可以纳入小腿并发症的预测/预防模型。据推测，当皮肤温度和灌注超出正常范围（升高）时，溃疡发展的可能性可能会增加。 所获得的数据将被纳入干预方案，以防止腿部静脉并发症。

DESCRIPTION (provided by applicant): Venous ulcers pose a serious health threat to over 2 millions Americans who suffer from them. It is critical to study individuals with chronic venous insufficiency (CVI), a known culprit of ulcers, in hopes of finding ways to prevent them. The purpose of this study is to measure skin temperature and tissue perfusion of both lower legs of older adults with CVI. The medial aspect of both lower legs above the malleolus (most vulnerable to ulceration) will be measured with an infrared thermometer to evaluate skin temperature and a laser Doppler flowmeter to evaluate tissue perfusion. The aim is to establish norm data and describe the correlation between skin temperature and tissue perfusion. The descriptive comparative study will compare skin temperature and tissue perfusion in a sample of 52 subjects (26 with CVI and 26 without CVI) at least 50 years of age recruited from various outpatient and community settings. Data will be analyzed using ANOVA and correlations. The findings of this study will add to the scant knowledge base regarding skin temperature and tissue perfusion of lower leg skin affected by CVI. The data will reveal whether these two "vital signs," particularly skin temperature, can be incorporated in a prediction/prevention model of lower leg complications. It is hypothesized that when skin temperature and perfusion are outside of a normal range (elevated), there may be an increased likelihood of ulcer development. The data obtained will be incorporated into an intervention protocol to prevent venous leg complications.