RISK FACTORS FOR INCIDENT ALZHEIMERS DISEASE

描述：(改编自《调查者摘要》)这是一个 之前的申请没有得到资助。它提议继续芝加哥 健康与老龄化项目(CHAP)--一项临床诊断的突发事件研究 阿尔茨海默病的6162名居民的地理定义，城市， 芝加哥南部的一个混血社区。这些研究的最新数据 表明阿尔茨海默病在黑人中的患病率是2.65倍 经年龄、教育程度和载脂蛋白E基因调整后，白种人高于白种人。建议数 工作检查了潜在的可修改的风险因素，特别是那些可能 解释风险的种族差异。主要问题是：(1)是否 血管因素，尤其是血压升高，会增加患高血压的风险 临床表现为阿尔茨海默病本身，除了他们接受的 在预测血管性痴呆风险中的作用，(2)这是否是中介的 通过小的脑梗塞和非梗塞相关的脑白质改变，以及 (3)血管因素在多大程度上解释了风险的种族差异 对疾病的恐惧？次要问题包括潜在的保护作用 抗炎药物和雌激素，早年接触对风险的影响 阿尔茨海默病的风险，以及血管因素预测风险的程度 血管性痴呆症。 为了实现这些目标，拟议的第二次后续行动(事件)数据收集 周期将检测在三年间隔内发生的阿尔茨海默病 自上一个周期以来，所有临床评估都将包括磁化 磁共振成像和磁共振以及地理学。此外，招生 当社区居民达到65岁时，他们的连续年龄段是 建议今后开展这项研究，以审查三个重要问题 这是现有研究无法检验的：风险因素的影响 对于阿尔茨海默氏症来说，年龄差异很大，暴露的必要性 一段较长时间内多个时间点的信息以及差异 不同年龄段人群中危险因素的发生及影响。

DESCRIPTION: (Adapted from the Investigator's Abstract) This is a revision of a previous application that was not funded. It proposes to continue the Chicago Health and Aging Project (CHAP), a study of incident clinically diagnosed Alzheimer's Disease among 6,162 residents of a geographically defined, urban, biracial community of the south side of Chicago. Recent data from the studies suggest that prevalence of Alzheimer's Disease is 2.65-fold higher among blacks than whites after adjustment for age, education and APOE genotype. The proposed work examines potentially modifiable risk factors, especially ones that might explain racial differences in risk. The primary questions are: (1) whether vascular factors, especially elevated blood pressure, increase risk of clinically manifest Alzheimer's Disease itself, in addition to their accepted role in predicting risk of vascular dementia, (2) whether this is mediated through small brain infarcts and non-infarct related white matter changes, and (3) to what extent do vascular factors account for racial differences in risk of disease? Secondary issues include potential protective effects of anti-inflammatory drugs and estrogens, effects of early life exposure on risk of Alzheimer's Disease, and the extent to which vascular factors predict risk of vascular dementia. To achieve these goals, a proposed second follow up (incidence) data collection cycle will detect Alzheimer's Disease occurring in the three year interval since the previous cycle, and all clinical evaluations will include magnetic resonance imaging and magnetic resonance and geography. In addition, enrollment of successive age cohorts of community residents as they reach age 65 is proposed to enable the study, in the future, to examine three important issues that cannot be examined by existing studies: whether effects of risk factors for Alzheimer's Disease vary greatly with age, the need for exposure information at multiple points over an extended period of time, and differences in the occurrence and effects of risk factors in different age cohorts.