SIGNAL TRANSDUCTION IN THE IMMUNE SYSTEM-FASEB CONF.

描述(由申请者提供)：本申请寻求为2003年6月14日至19日在科罗拉多州斯诺马斯举行的FASEB夏季会议“免疫系统中的信号转导”提供部分资金。会议的主要目标是全面关注免疫细胞信号机制知识的最新进展。对信号转导途径的了解是了解各种免疫功能的分子基础的核心，这些免疫功能涉及对传染病、过敏、移植和恶性肿瘤的反应。大学、研究机构和生物技术对免疫细胞信号转导有着广泛的兴趣。然而，免疫学会议上的信号转导通常被作为一个辅助主题涵盖，几乎没有详细的报道。2000年，关于“免疫系统中的信号转导”的第一次FASEB会议深入讨论了免疫系统中信号转导的细节。那次会议的成功使一些调查人员相信了定期会议的价值。2003年的会议将涵盖一系列主题，从蛋白质和脂肪激酶和磷酸酶到适配蛋白(SLP-76、LAT、ADAP、3BP-2等)、质膜生物学以及基础生物学和疾病环境中的效应酶。本次会议将有三个主要目标：(1)对控制各种免疫功能的信号蛋白的现状进行关键和深入的概述。我们的会议将涵盖从对特定信号分子和网络的深入分析到将这一知识应用于免疫生物学的全方位主题。(2)将资深科学家和青年研究人员聚集在介绍和非正式讨论的欢乐气氛中。希望这种环境将有助于发展学生和年轻调查人员的调查技能和热情，通过与老牌调查人员进行互动。(3)继续为对全面关注免疫系统中的信号事件感兴趣的研究人员举办一年两次的论坛。

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Conference on "Signal Transduction in the Immune System" to be held from June 14th-19th, 2003 in Snowmass, Colorado. The major goal of the conference is to provide a comprehensive focus on recent advances in the knowledge of signaling mechanisms of immune cells. An understanding of signal transduction pathways is central to an understanding of the molecular basis of various immune functions involved in the response to infectious disease, allergy, transplantation and malignancy. Widespread interest of immune cell signaling exists in universities, research institutes and biotechnology. However, signal transduction at immunology meetings is generally covered as an adjunct subject, with little detailed coverage. In 2000 the first FASEB meeting on "Signal Transduction in the Immune System" provided an in-depth focus on the details of signal transduction in the immune system. The success of that meeting convinced a number of investigators of the value of a regular meeting. The 2003 meeting will cover a spectrum of topics from protein and lipid kinases and phosphatases to adapter proteins (SLP-76, LAT, ADAP, 3BP-2 etc.), plasma membrane biology and effector enzymes in basic biology and disease settings. There will be three main objectives of this conference: (1) To provide a critical and intensive overview of the current status of signaling proteins that control various immune functions. Our meeting will cover a full-range of topics from an in depth analysis of specific signaling molecules and networks to the application of this knowledge to immunobiology. (2) To bring together senior scientists and young investigators in a convivial atmosphere of presentations and informal discussions. It is hoped that this environment will help develop the investigative skills and enthusiasm of students and young investigators by interacting with established investigators. (3) To continue a biannual forum for investigators interested in a comprehensive focus on signaling events in the immune system.