Slipstream Visualization Technology for MRI/A Phantoms

描述(由申请人提供)： 由于缺乏相关的商业血流模型，同时评估心血管解剖和血流动力学的无创性MRI应用的发展受到阻碍。此前，创新技术被开发出来，以基于图像数据、逼真的壁力学和分支的次级血管来设计增强的颈动脉分叉和冠状动脉模型。我们建议扩展这些能力，以包括与以下相关的局部血流动力学增强：1)与临床风险相关的管腔壁特征；2)局部冠状动脉血流受损。这将通过首先开发门控流体输送系统(FDS)(目标1)来实现。然后利用FDS的功能：1)滑流可视化技术(SVT)和2)定量血管床流(VBF)(AIM2)。1)通过光学和实时MR血流图像记录滑流可视化，并将结果与先进的CFD模拟进行比较，为SVT建立概念验证；2)VBF通过为冠状动脉储备研究提供多个定义的冠脉流量随区域变化而建立(Aim 3)。结果和问题被记录在案，并为第二阶段(目标4)确定了改进功能和人体工程学的途径。解剖和流动的组合可视化(测量和模拟)提供了目前无法用于模型验证和应用程序开发的关键信息。

DESCRIPTION (provided by applicant): Development of noninvasive MRI applications to simultaneously evaluate cardiovascular anatomy and flow dynamics is hampered by the lack of relevant commercial flow phantoms. Previously, innovative technology was developed to produce enhanced carotid bifurcation and coronary artery phantoms with design based on image data, realistic wall mechanics and branching secondary vessels. We propose to extend these capabilities to include enhancement of local flow dynamics associated with: 1) lumen wall features linked to clinical risk and 2) regionally impaired coronary flow. This will be accomplished by first developing a gated fluid delivery system (FDS) (Aim 1). Then exploiting FDS capabilities for: 1) slipstream visualization technology (SVT) and 2) quantitative vascular bed flow (VBF) (Aim2). Proof-of-concept is established for 1) SVT by documenting slipstream visualization optically and in real-time MR flow images with results compared to advanced CFD simulations and 2) VBF by delivering multiple defined volumes of coronary flow with regional variations for coronary reserve studies (Aim 3). Results and issues are documented and pathways to improved functionality and ergonomics are identified for Phase II (Aim 4). Combined visualization of anatomic and flow (measured & simulated) provides critical information not currently available for model validation and application development.