Fully Implantable Mini-Mixed-Flow Pump

描述（由申请人提供）： 这项快速通道资助的第一阶段将成功地展示一种永久植入式微型混流泵概念，用于极小的右心室辅助装置（RVAD）。第二阶段的目标是开发和演示产品原型。原型泵设计将根据第一阶段的经验进行优化，并将设计和制造定制电机控制器。将对系统进行性能、溶血和长期耐久性台架测试。将在小牛中进行一系列RVAD示范试验。还将创建一个Bi-VAD系统并进行台架测试;该Bi-VAD将RVAD与MagScrew VAD和MagScrew TAH的支持组件相结合。作为拟议努力的结果，完全植入式RVAD将可集成到Bi-VAD系统中。这将为每年估计需要双心室辅助的10，000至20，000名患者提供有效的治疗方式。

DESCRIPTION (provided by applicant): Phase I of this Fast-Track grant will successfully demonstrate a Mini-Mixed-Flow pump concept for a permanently implantable, extremely small right ventricular assist device (RVAD). The goal of Phase II is to develop and demonstrate a product prototype. The prototype pump design will be optimized, based on Phase I experience, and a custom motor controller will be designed and fabricated. The system will be bench tested for performance, hemolysis, and long-term endurance. A series of RVAD demonstration tests in calves will be performed. A Bi-VAD system will also be created and bench tested; this Bi-VAD will combine the RVAD with a MagScrew VAD and the supporting components of a MagScrew TAH. As a result of the proposed effort, a fully implantable RVAD will become available for integration into a Bi-VAD system. This will provide an effective treatment modality for the 10,000 to 20,000 patients per year who are estimated to need bi-ventricular assistance.