Mechanisms and Regulation of ACE2 Shedding

高血压和心脏病是影响澳大利亚25%以上人口的重大健康问题。我们最近发现，心脏病发作后，心脏组织中一种名为ACE2的参与心血管调节的新酶大大增加。此外，我们有证据表明这种酶在心脏病发作后或慢性肝损伤后释放到血液中。目前的项目旨在扩展我们的初步数据，并了解心血管和肝脏疾病中ACE2分泌机制的基础生物学。此外，血浆中ACE2的测量可以提供关于预后的有用信息，并且ACE2分泌的潜在机制的知识可以定义新的治疗靶点以治疗和预防心血管和肝脏疾病

High blood pressure and heart disease, are a significant health issue affecting more than 25% of the Australian population. We have recently found that a new enzyme called ACE2 involved in cardiovascular regulation is greatly increased in heart tissue following heart attack. Furthermore, we have evidence that this enzyme is released into the blood after a heart attack or as a consequnce of chronic liver injury. The current project aims to expand on our preliminary data and to understand the basic biology underlying the mechanism of ACE2 secretion in cardiovascular and liver diseases. In addition, the measurement of ACE2 in plasma may provide useful information on prognosis and knowledge of the mechanism underlying ACE2 secretion may define new therapeutic targets to treat and prevent cardiovascular and liver disease