RESEARCH TRAINING IN PHYSIOLOGICAL ADAPTATION TO STRESS

项目说明：（由申请人提供）本项目第一期“生理适应压力研究训练”博士点培养项目吸引了一批优秀学生，5名毕业生获得了一流的博士后或行业岗位。目前，60%的NIH资助名额由少数民族学生填补。在这一成功的基础上，我们寻求在未来五年继续支持该计划。对压力的生理适应包括从影响细胞代谢的分子结构改变到生物体重塑的广泛反应。适应可能是积极的，如增加参加有规律的体育活动，也可能有病理后遗症，如创伤后的高代谢反应。我们的博士前培训项目充分利用了宾夕法尼亚州立大学好时校区医学院和大学公园校区几个院系现有的国际公认的师资力量。正在进行的培训计划的目标是培养科学家产生、整合和应用通过多种方法收集的知识来研究应激生理学的能力。该培训项目将继续在跨学院生理学研究生项目中进行，该项目在跨学科研究生教育方面已有35年的历史。培训项目的教师致力于通过招募少数族裔来增强多样性，并促进研究中的道德规范。该培训计划每年为8名博士预科生提供支持，他们将通过严格的课程、结构化的研究经验和专门的指导，熟练地整合在多个调查层面收集的信息。专门为这个项目开发了一门核心课程，“生理适应压力”，并继续作为这个培训项目目标的早期介绍。两个校区都提供了丰富的学术环境，具有强大的研究支持和机构承诺。宾夕法尼亚州立大学将继续提供4个全额助教奖学金，作为这项培训补助金的匹配。通过该课程完成培训的学生不仅将掌握从分子到整个生物体的实验室技术的全面知识，而且还将具备理解和综合来自研究生理适应压力的复杂信息的能力。

DESCRIPTION: (provided by applicant) The predoctoral training program entitled "Research Training in Physiological Adaptations to Stress" during its first funding period, has attracted excellent students and the five graduates of the program have obtained first rate postdoctoral positions or positions in industry. Sixty percent of the NIH funded slots are currently filled with minority students. Based on this success, we seek continued support of the program for another five years. Physiological adaptations to stress encompass a wide range of responses from alterations of molecular structure affecting cellular metabolism to organismal remodeling. Adaptations may be positive, such as those brought about by increased participation in regular physical activity, or they may have pathological sequelae such as hypermetabolic responses to trauma. Our predoctoral training program takes advantage of the existing, internationally recognized strengths of faculty located at the College of Medicine at the Hershey Campus and within several departments at the University Park campus of The Pennsylvania State University. The goal of the ongoing training program is to develop scientists with an ability to generate, integrate, and apply knowledge gathered by multiple approaches to the study of stress physiology. The training program will continue to be housed in the Intercollege Graduate Program in Physiology, which has a thirty-five year history of interdisciplinary graduate student education. Faculty members of the training program are committed to enhancing diversity through minority recruitment and to promoting ethics in research. The training program seeks support for 8 predoctoral trainees per year whose proficiency to integrate information gathered at many levels of inquiry will be developed by a rigorous curriculum, structured research experiences and dedicated mentorship. A core course has been developed specifically for this program, "Physiological Adaptations to Stress and continues to serve as an early introduction to the goals of this training program. A rich academic environment is provided at both campuses with strong research support and institutional commitment. The Pennsylvania State University will continue to provide four full assistantships as a match for this training grant. Students who complete their training through this program will not only have a thorough knowledge of laboratory techniques ranging from molecular to whole organism, but they will also have the capacity to understand and synthesize complex information resulting from research examining the physiological adaptations to stress.