Mind/Brain/Body Interactions in Stress-Related Disorders

描述(申请人提供)：几种常见的慢性疾病，包括慢性内脏和躯体疼痛综合征，情绪和情感障碍，以及成瘾行为，可能与中枢应激系统的神经生物学改变有关。其中一些疾病，包括功能性胃肠道功能障碍、抑郁症和焦虑症，在妇女中更为常见，会导致相当大的发病率和生活质量的损害，而且通常没有令人满意的、成本效益高的治疗方法。加州大学洛杉矶分校神经内脏科学和妇女健康中心(CNS/WH)是最近由美国国立卫生研究院资助的P50中心，它召集了大量对心理/身体互动感兴趣的临床和基础研究人员，尤其对压力和基于性别的差异在改变这些互动在健康和疾病中的作用感兴趣。鉴于许多正在进行的跨学科、跨部门以及外部合作，涉及广泛的分子、行为、脑成像和健康结果研究，拟议的基础设施支持拨款将极大地扩展现有中心的广度和深度，并利用现有的NIH中心支持。因此，在目前的申请中，我们提议建立4个科学核心，并为现有的一个小型行政核心提供补充支助。此外，我们还提出了几个发展和公共基础设施组成部分。在赠款的头两年，4个研究核心(健康结果、神经成像、动物模型、心理生理学和疼痛评估)中的每一个都将有2-3个开发项目。这些项目的主要目标是为每个核心开发新的、尖端的专门知识和技术。在完全建立了核心之后，我们提出了一个试点和可行性计划，为期3-5年，每年颁发4个奖项。这些项目将利用核心的资源以及相关教员的专业知识。此外，我们提出了一个职业发展计划，以命名的新调查员奖的形式，最长限制为2年。基于对健康和疾病中精神/大脑相互作用的各个方面感兴趣的临床和基础科学家的异常数量，基础设施支持将极大地促进加州大学洛杉矶分校的精神/身体医学的可见度，产生最高质量的研究，并培训这一新兴领域的一流翻译研究。

DESCRIPTION (provided by applicant): Several common chronic disorders including chronic visceral and somatic pain syndromes, disorders of mood and affect, and addictive behaviors can be related to alterations in the neurobiology of the central stress system. Some of these disorders, including functional GI disorders, depression and anxiety are significantly more common in women, cause considerable morbidity and impairment in quality of life and satisfactory, cost-effective treatments are generally not available. The UCLA Center for Neurovisceral Sciences & Women's Health (CNS/WH), a recently NIH-funded P50 Center has assembled a large number of clinical and basic investigators interested in Mind/Body interactions with a particular interest in the role of stress and sex-based differences in altering these interactions in health and disease. In view of many ongoing interdisciplinary and interdepartmental, as well as outside collaborations, spanning a wide range of molecular, behavioral, brain imaging and health outcomes studies, the proposed infrastructure support grant would greatly expand the breadth and depth of the existing center and leverage the existing NIH center support. In the current application, we are therefore proposing the establishment of 4 scientific cores together with a supplementary support for a small existing administrative core. In addition, we are proposing several developmental and public infrastructure components. During the first two years of the grant, each of the 4 research cores (Health Outcomes, Neuroimaging, Animal Models, Psychophysiology and Pain Assessment) will have 2-3 development projects attached to it. The primary goal of these projects is the development of novel, cutting edge expertise and technologies for each core. After the full build up of the cores, we propose a Pilot and Feasibility program for years 3-5 of the grant with 4 annual awards. These projects will utilize the resources of the cores as well as the expertise of the involved faculty. In addition, we propose a career development program in form of a Named New Investigator award limited to a maximum of 2 years. Based on the unusual number of clinical and basic scientists interested in various aspects of Mind/Brain interactions in health and disease, the infrastructure support would greatly contribute to the visibility of Mind/Body medicine at UCLA, to the generation of highest quality research and to the training of first rate translational researches in this emerging field.