UTMB MASS SPECTROMETRY/PROTEOMICS FACILITY

描述：（申请人的描述）本提案旨在开发一种 质谱/蛋白质组学设施，为UTMB研究人员提供 增强分析能力，以识别和表征蛋白质 与癌症和蛋白质表达的肿瘤学变化相关。那里 在UTMB大约有37个NCI支持的赠款， 目前的直接成本资金约为1320万美元。其中七 描述NCI支持的项目是为了强调以下方面的至关重要性： 在UTMB开发质谱和蛋白质组学核心设施。这 该设施将在UTMB蛋白质化学实验室内运行， 建立了集中的核心服务，具有提供 UTMB研究社区提供与蛋白质相关的分析服务， 肽和氨基酸。该补助金将允许UTMB癌症研究人员 利用新的发展和能力， 蛋白质/肽的质谱表征，因此相当大 加强NCI支持的校园研究。资金将首先 用于购买蛋白质组学设备，并在持续的基础上，提供 必要的人员，物资和部分服务合同，以运作 设施。还要求提供支持，以激励新的和年轻的调查人员 癌症研究，提供尖端技术，用于识别 疾病相关蛋白表达。除了七个描述的NCI- 资助的项目，UTMB的其他NIH研究人员也有望 受益于这一赠款。总的来说，这笔赠款将 大幅降低分析的收费，从而鼓励 癌症研究人员利用这一资源。 UTMB的承诺 发展这一设施的重要贡献是， 空间、设备和工资支持。一个咨询委员会已经到位， 确保赠款的目标得以实现，该设施将 在未来几年继续运作。

DESCRIPTION: (Applicant's Description) This proposal is aimed at developing a mass spectrometry/proteomics facility to provide UTMB investigators with enhanced analytical capabilities to identify and characterize proteins associated with cancer and oncological changes in protein expression. There are approximately 37 NCI-supported grants at UTMB with a combined total current direct cost funding of about $13.2 million dollars. Seven of these NCI-supported projects are described to underscore the critical importance of developing a mass spectrometry and proteomics core facility at UTMB. This facility will operate within the UTMB Protein Chemistry Laboratory, an established centralized core service that has a strong history of providing the UTMB research community with analytical services relating to proteins, peptides, and amino acids. This grant will allow UTMB cancer researchers to take advantage of new developments and capabilities in the area of protein/peptide characterization by mass spectrometry, and so considerably enhance NCI-supported research on the campus. Grant funds will be initially used to purchase proteomics equipment, and on an ongoing basis, to provide the necessary personnel, supplies, and partial service contracts to operate the facility. Support is also requested to stimulate new and young investigator cancer research by providing cutting-edge technology for the identification of disease-associated protein expression. In addition to the seven described NCI- funded projects, other NIH research investigators at UTMB are also expected to benefit from this grant. In general, funding from this grant will significantly reduce the charge-back fees for analyses, and so encourage cancer investigators to utilize this resource. UTMB's commitment to developing this facility is underscored by a considerable contribution of space, equipment, and salary support. An advisory committee is in place to insure that the goals of the grant are achieved and that the facility will continue to operate into future years.