The Epidemiology of Marine Fatty Acids and Preeclampsia

描述：（由申请人提供）先兆子痫的病因不明。 简而言之，几项研究的结果（通常是不控制的小型研究） 混杂因素）表明母体抗氧化剂和 促氧化剂状态可能与先兆子痫的风险增加有关。 也有新的证据表明，母亲和母亲之间的联系。 促炎状态和先兆子痫风险增加。在这场竞争中， 更新的申请，我们寻求建立在这方面的工作，继续 前瞻性研究（海洋脂肪酸和先兆子痫的流行病学：RO 1 HD 32562），并战略性地整合新的生物标志物， 更好地描述先兆子痫的流行病学特征。这项研究是一个队列研究， 这项研究对1,500名怀孕早期的孕妇进行了随访， 交付.我们计划将这一队列扩大到总共招募4，200人 未生育的妇女。我们将使用嵌套病例队列设计和多变量 用逻辑分析方法评估先兆子痫风险与 具有母体抗氧化剂的生物标志物（酶和非酶） status.此外，我们还将评估关于母亲慢性 促炎状态[通过高敏C反应蛋白测定 （hs-CRP）和促炎性细胞因子包括肿瘤坏死因子-a （TNF-α）]可溶性受体（sTNFp 55和sTNFp 75）与先兆子痫的关系 风险我们的总体目标是测试是否饮食，免疫， 其他生活方式特征与随后的 发展为先兆子痫我们努力的结果应该提供更多的 关于内皮功能障碍的机制基础的知识， 先兆子痫风险。此外，我们的结果应该提供信息， 用于推动制定预防干预战略 足以影响先兆子痫的发生。结果 拟议的研究对开发替代品， 对先兆子痫和其他不良反应的实际预防干预 妊娠结果（例如，胎儿生长迟缓和早产）。 抗氧化剂和微量金属，如锌和硒（这是重要的 抗氧化酶的活性），以及铁可以很容易地 通过补充剂的使用或特定食物的选择在饮食中进行操纵 如果这项研究和其他研究的证据表明有益的话。

DESCRIPTION: (provided by applicant) The etiology of preeclampsia is unknown. Briefly, results from several studies (typically small studies not controlling for confounding) suggest that an imbalance in maternal antioxidant and pro-oxidant status may be associated with an increased risk of preeclampsia. There is also emerging evidence suggestive of an association between maternal proinflammatory status and increased risk of preeclampsia. In this competing renewal application, we seek to build on this body of work by continuing the prospective study (Epidemiology of Marine Fatty Acids and Preeclampsia: RO 1 HD 32562), and strategically integrating new biological markers that will serve to better characterize the epidemiology of preeclampsia. The study is a cohort study of 1,500 pregnant women enrolled early in pregnancy and followed until delivery. We plan to expand this cohort to include enrolling a total of 4,200 nulliparous women. We will use a nested case-cohort design and multivariate logistic analytical methods to assess the relation between risk of preeclampsia with biological markers of maternal antioxidant (enzymatic and non-enzymatic) status. Additionally, we will assess hypotheses concerning maternal chronic pro-inflammatory status [as measured by high sensitivity C-reactive protein (hs-CRP) and the pro-inflammatory cytokines including tumor necrosis factor-a (TNF-a)] soluble receptors (sTNFp55 and sTNFp75) in relation to preeclampsia risk. Our overall objective is to test whether dietary, immunological, and other lifestyle characteristics are associated with subsequent risk of developing preeclampsia. Results from our efforts should provide additional knowledge concerning the mechanistic basis for endothelial dysfunction and preeclampsia risk. Furthermore, our results should provide information that may be used to motivate the development of prevention intervention strategies sufficient for impacting the occurrence of preeclampsia. Results from the proposed study could have practical significance in developing alternative, practical preventative interventions for preeclampsia and other adverse pregnancy outcomes (e.g., fetal growth retardation and preterm delivery). Antioxidants, and trace metals such as zinc and selenium (which are important to the activity of antioxidant enzymes), as well as iron could be easily manipulated in the diet either by supplement use or by specific choice of foods if evidence from this and other studies indicates a benefit.