Mechanisms of virally-induced immunosuppression: effects on DC-NK networks

巨细胞病毒（CMV）感染诱导免疫抑制，往往导致不良的临床结果。我们以前的工作确定了树突状细胞（DC），参与免疫应答启动的细胞，是CMV的主要靶点。该提议将检验CMV诱导的免疫抑制是由病毒干扰DC介导的假设。了解诱导免疫抑制的机制是开发更好疗法的关键一步。

Cytomegalovirus (CMV) infection induces immunosuppression that often results in adverse clinical outcomes. Our previous work established that dendritic cells (DC), cells involved in the initiation of immune responses, are a principle target for CMV. This proposal will test the hypothesis that CMV-induced immunosuppression is mediated by viral interference with DC. Understanding the mechanisms involved in the induction of immunosuppression is a crucial step towards developing better therapies.