Biobehavioral Oncology Training Program

摘要 这个新的T32重新提交申请支持生物行为学博士后研究培训计划 在密尔沃基的威斯康星州医学院（MCW）的肿瘤学。为期两年的生物行为肿瘤学 培训（BBOT）计划每年将支持两名新研究员，稳定状态为四名，未来总计为10名 融资期。我们的计划整合了癌症差异的交叉主题，从预防到治疗， 生存。我们的导师是MCW癌症中心的成员，该中心正朝着NCI发展 名称. BBOT计划是一个跨学科的计划，认为生物和生物技术的贡献， 行为因素对癌症的预防、控制和治疗反应通过两个主题的整合： 1)压力和差异的生物学，以及2）健康，行为和结果的社会决定因素。是 在威斯康星州的第一个培训计划，以解决癌症预防的生物和行为方面， 控制和第一个癌症为重点的培训计划在MCW。本提案的主要目的是 来自不同人群的成功的独立癌症研究领导者，以治疗癌症 通过将生物学和行为学方面纳入癌症研究，BBOT将成为 在20名主要导师的支持下，所有受资助的PI每年获得1800万美元的癌症相关校外资助 支持.导师包括12个部门任命的13名博士，6名医学博士和1名医学博士/博士， 跨部门项目。此外，六名具有相关专业知识的初级导师将参加初级 导师计划，担任BBOT学员的副导师。总的来说，导师们 流行病学、基础癌症生物学、遗传学、生物统计学、神经科学、免疫学和 行为医学和干预措施，提供研究机会，重点是遗传， 分子、神经、心理、行为和社会因素及其对癌症的影响。由一名 个性化的发展计划，培训计划包括四个组成部分，旨在培养学员， 启动和维持成功的研究事业：i）教学式学习; ii）多学科生物行为肿瘤学 指导研究经验; iii）职业发展; iv）社区参与。密尔沃基是第五个 威斯康星州是美国最贫穷、种族隔离最严重的城市之一，也是威斯康星州大多数非洲人的家园。 美国，西班牙裔和苗族社区。BBOT的经验和培训目标旨在发展 一群多元化的科学家，他们将致力于改善持续存在的癌症差异， 在我们的城市和全国各地都有体现。内部和外部咨询委员会将提供持续的 评估和反馈，以确保计划目标得到有效实现。BBOT拥有热情和强大的 来自项目主任部门主席、MCW癌症中心主任和 MCW医学院的院长，他们都分配了大量的资源，以确保其成功。

ABSTRACT This new T32 resubmission application supports a postdoctoral research training program in biobehavioral oncology at the Medical College of Wisconsin (MCW) in Milwaukee. The two-year Biobehavioral Oncology Training (BBOT) Program will support two new fellows per year for a steady state of four and total of 10 over the funding period. Our program integrates the cross cutting theme of cancer disparities from prevention to survivorship. Our preceptors are members of MCW's Cancer Center, which is on a strong trajectory toward NCI designation. The BBOT Program is an interdisciplinary program that considers the contribution of biological and behavioral factors to cancer prevention, control and treatment response through the integration of two themes: 1) the biology of stress and disparities, and 2) social determinants of health, behavior, and outcomes. It is the first training program in Wisconsin to address the biological and behavioral aspects of cancer prevention and control and the first cancer-focused training program at MCW. The primary objective of this proposal is to produce successful independent cancer research leaders who come from diverse population groups to remediate cancer health disparities by incorporating biological and behavioral aspects into their cancer research. BBOT will be supported by 20 primary mentors, all funded PIs with grants totaling $18M in annual cancer-relevant extramural support. Mentors include 13 PhDs, six MDs, and one MD/PhD appointed in 12 departments and interdepartmental programs. Additionally, six junior mentors with relevant expertise will participate in a Junior Mentoring Program, serving as associate mentors to BBOT trainees. Collectively, mentors have outstanding expertise in epidemiology, basic cancer biology, genetics, biostatistics, neuroscience, immunology, and behavioral medicine and interventions, offering research opportunities focusing on the interactions of genetic, molecular, neural, psychological, behavioral and social factors and their impact on cancer. Informed by an individualized development plan, the training program includes four components designed to prepare trainees to launch and sustain successful research careers: i) didactic learning; ii) multidisciplinary biobehavioral oncology mentored research experience; iii) career development; and iv) community engagement. Milwaukee is the fifth poorest and one of the most segregated cities in the US and is home to the majority of Wisconsin's African American, Hispanic and Hmong communities. The BBOT experience and training goals are designed to develop a diverse cadre of scientists who will dedicate their careers to ameliorating the persistent cancer disparities manifest in our city and across the nation. Internal and External Advisory Committees will provide ongoing evaluation and feedback to ensure that program goals are effectively met. BBOT has enthusiastic and robust institutional support from the Program Directors' department chairs, the MCW Cancer Center director, and the dean of the MCW School of Medicine, all of whom have allocated substantial resources to ensure its success.