Mechanistic and Functional Drivers of Neochromosome Evolution

新染色体是弗兰肯斯坦染色体--从100多条正常染色体中拼接而成的大量额外染色体。它们在3%的癌症中被发现，但在某些类型中很常见，如脂肪肉瘤。我们绘制了它们的结构图，发现它们是通过间断的染色体破碎和基因扩增形成的。我们将研究导致这种情况的精确分子机制以及导致其形成的经常性转录和表观遗传驱动因素。

Neochromosomes are Frankenstein chromosomes--massive extra chromosomes that are stitched together from 100s of pieces of normal chromosomes. They are found in 3% of cancers, but are common in some types, such as liposarcoma. We have mapped their structure and found they form through punctuated chromosome shattering and gene amplification. We will investigate the precise molecular mechanisms that cause this and the recurrent transcriptional and epigenetic drivers lead to their formation.