T32 Training Program in Cancer Biology

项目总结 我们对癌症生物学的理解的进步有可能导致在以下方面的重大突破 癌症诊断和治疗；然而，将基础科学发现转化为临床进步 由于对基础科学家和临床医生的二分法培训，这一点受到了损害。因此，有一个令人信服的 需要增强的有指导的研究培训计划，以弥合严谨培训与 遵循科学的方法进行科学的调查，对患者进行体贴的临床护理。我们建议 一个癌症生物学培训计划，将利用优秀的资源，高水平的 研究人员，以及温希普癌症研究所癌症生物学家和临床医生之间的密切合作 埃默里大学，佐治亚州第一个也是唯一一个由NCI指定的综合性癌症中心，提供一个独特的， 个性化、多方面的培训经验，支持博士后学员的发展 获得解决最重要的生物学问题和具有临床意义的知识和技能 这样他们就可以做出革命性的发现，以提高癌症患者的护理质量。 埃默里癌症生物学培训计划的目标是为博士后实习生提供 基础设施、资源、培训、经验和指导，以获得深入的知识和关键 癌症生物学研究的技能与临床概念的实际接触和理解相结合 启动一项有影响力的独立研究计划，将癌症生物学的新见解转化为 改善临床护理。培训计划的目标包括：1)有组织的研究培训；2) 全面的正式和非正式教学，3)通过肿瘤委员会和诊所的临床暴露，4)职业生涯 发展活动，以及5)向独立过渡的计划。该项目将培养两名新的博士后 第一年的学员人数，第二年再增加两名学员，每名学员共四名 一年又一年。博士后实习生将从异常强大和广泛的 在博士后培训的头两年内申请博士和/或医学博士，并将完成12-24年 几个月的全职指导研究。学员将有机会在 由22名资金雄厚、经验丰富的导师和初级导师组成的多学科小组的实验室与 一位来自10个基础科学和临床科室的高级共同导师，他们都是三个部门的正式成员 温希普癌症研究所的互补和协同研究计划：1)细胞和分子生物学， 2)癌症免疫学，3)发现和发展治疗学。所有受训人员将被要求参加 一个至少有一名临床导师的指导委员会。杰出的机构承诺和重点放在 包容性优秀包括每年为招聘增加一个博士后实习生职位提供支持 代表不足的实习生，为PI、管理人员和实习生提供的工资支持，以及博士后办公室 教育资源。该计划旨在培养下一代癌症科学带头人。

PROJECT SUMMARY Advances in our understanding of the biology of cancer have the potential to lead to significant breakthroughs in cancer diagnosis and treatment; however, the translation of basic science discoveries to clinical advancement has been impaired by the dichotomous training of basic scientists and clinicians. Thus, there is a compelling need for an enhanced mentored research training program that will bridge the gap between training in rigorous scientific investigation following the scientific method and compassionate clinical care for the patient. We propose a Training Program in Cancer Biology that will take advantage of the outstanding resources, high caliber of investigators, and close collaboration between cancer biologists and clinicians at the Winship Cancer Institute of Emory University, Georgia’s first and only NCI-designated comprehensive cancer center, to provide a unique, individualized, and multi-faceted training experience to support the development of postdoctoral trainees in acquiring the knowledge and skills to address the most important biological questions and clinically significant problems so that they can make transformative discoveries to improve quality of care for patients with cancer. The objective of the Emory Training Program in Cancer Biology is to provide postdoctoral trainees with the infrastructure, resources, training, experience, and mentorship to acquire the depth of knowledge and critical skills in cancer biology research combined with the practical exposure and understanding of clinical concepts to initiate an impactful independent research program that will translate novel insights in cancer biology into improvements in clinical care. Aims of the training program include: 1) Organized research training, 2) Comprehensive formal and informal didactics, 3) Clinical exposure through tumor boards and clinics, 4) Career development activities, and 5) Plan for transition to independence. The program will train two new postdoctoral trainees in the first year followed by an additional two trainees in the second year for a total of four trainees per year by the second year. Postdoctoral trainees will be rigorously selected from an exceptionally strong and broad applicant pool of PhD and/or MDs within the first two years of their postdoctoral training and will complete 12-24 months of full-time mentored research. Trainees will have the opportunity to engage in independent research in the labs of a multidisciplinary group of 22 well-funded and experienced Mentors and junior Mentors paired with a senior co-Mentor from 10 basic science and clinical departments who are all full members of three complementary and synergistic research programs of the Winship Cancer Institute: 1) Cell and Molecular Biology, 2) Cancer Immunology, and 3) Discovery and Developmental Therapeutics. All trainees will be required to form a Mentoring Committee with at least one clinical mentor. Outstanding institutional commitment and focus on inclusive excellence includes support for an additional postdoctoral trainee position per year for the recruitment of an underrepresented trainee, salary support for the PI, administrators, and trainees, and Office of Postdoctoral Education resources. This program intends to train the next generation of cancer scientific leaders.