Center of Integrated Biomedical and Bioengineering Research (CIBBR)

项目摘要/摘要(总体核心) 新汉普郡大学(UNH)第一个科布雷：综合生物医学和 生物工程研究(CIBBR)极大地促进了生物医学和生物工程研究的发展 第一阶段期间的环境。这些收益可归因于四个主要进展：(A)战略 对研究项目的投资和为13名早期(外加4名职业中期)UNH教员提供的试点项目资金 开展生物医学和生物工程研究；(B)由CIBBR专门指导这些教员 领导团队和外部科学导师；(C)在研究基础设施方面取得重大进展，包括 收购最先进的仪器设备并创造分子和细胞表型核心， 以及；(D)通过对新的手段和补充作出机构贡献，扩大这一基础设施 在UNH的大学仪器中心内的新技术人员。 这一第二阶段应用的总体目标是进一步推进生物医学和生物工程研究 通过实施教师“集群聘用”，以及新的数据科学核心和其他增强功能 研究基础设施-将加快UNH的严谨、多学科研究，以推进 将生物医学发现转化为改善人类健康的应用解决方案。我们会做到这一点的 通过以下具体目标：目标1.扩大和加强本中心的研究、管理 业务和评估方案，以进一步加强在UNH进行NIH- 资助生物医学和生物工程研究。目标2.创建一大批由NIH资助的调查人员 通过招聘早期调查人员，加强多方面的指导和职业生涯 为CIBBR调查人员制定的发展计划。 在CIBBR二期工程完成后，我们将战略性地增加生物医学研究 通过“集群”雇用早期调查人员和高级生物医学和 生物工程研究人员，并改进和扩大了CIBBR教师的指导。这将是 同时创建了数据科学核心，并购置了额外的研究仪器 分子和细胞表型核心。这些行动将对以下方面产生强大和持续的影响 通过扩大NIH资助的教员数量，在UNH进行生物医学和生物工程研究 研究。加强UNH和外部研究人员应用多学科和多组学的能力 方法将增加我们对基础生物医学科学和生物工程的知识，加快 开发与临床相关的诊断工具和治疗方法，并推进生物医学劳动力培训 NH州的容量。

PROJECT SUMMARY/ABSTRACT (OVERALL CORE) The University of New Hampshire’s (UNH) first COBRE: Center of Integrated Biomedical and Bioengineering Research (CIBBR) has substantially improved the biomedical and bioengineering research environment during Phase 1. These gains can be attributed to four major advancements: (a) strategic investments in Research Project and Pilot Project funding for 13 early-stage (plus 4 mid-career) UNH faculty conducting biomedical and bioengineering research; (b) dedicated mentoring of these faculty by the CIBBR Leadership Team and External Scientific Mentors; (c) major gains in research infrastructure, including the acquisition of state-of-the-art instrumentation and creation of the Molecular and Cellular Phenotyping Core, and; (d) the amplification of this infrastructure by institutional contributions to new instrumentation and addition of new technical staff within UNH’s University Instrumentation Center. The overall goal of this Phase 2 application is to further advance biomedical and bioengineering research by implementing a faculty “cluster hire” that—together with a new Data Science Core and other enhancements to research infrastructure—will accelerate rigorous, multidisciplinary research at UNH to advance the translation of biomedical discoveries to applied solutions that improve human health. We will accomplish this through the following specific aims: Aim 1. Expand and strengthen our Center’s research, administrative operations, and evaluation programs to further enhance the research environment at UNH for conducting NIH- funded biomedical and bioengineering research. Aim 2. Create a critical mass of NIH-funded investigators through recruitment of early-stage investigators supported by enhanced multi-component mentoring and career development programs for CIBBR investigators. Upon completion of Phase 2 of CIBBR, we will have strategically increased the biomedical research capacity at UNH through “cluster” hiring of both early-stage investigators and senior biomedical and bioengineering researchers and improved and expanded the mentoring of CIBBR faculty. This will be accompanied by the creation of a Data Science Core and acquisition of additional research instrumentation for the Molecular and Cellular Phenotyping Core. These actions will have a powerful and sustained impact on biomedical and bioengineering research at UNH by expanding the number of faculty performing NIH-funded research. Enhancing the capacity of UNH and external researchers to apply multidisciplinary and multi-omics approaches will increase our knowledge of basic biomedical science and bioengineering, expedite the development of clinically relevant diagnostic tools and treatments, and advance biomedical workforce training capacity in the State of NH.