Molecular and Cellular Phenotyping (MCP) Core

项目总结(分子和细胞表型核心) 作为UNH COBRE的主要研究核心组成部分：综合生物医学和 生物工程研究(CIBBR)，分子和细胞表型分析(MCP)核心的总体目标是 使新技术能够将严格的多学科研究转化为生物医学和 生物工程解决方案，同时明智地管理MCP核心研究基础设施以确保长期 可持续发展。第二阶段的目标是：(1)任命具有适当专业知识的CIBBR教师来服务 作为MCP三个子核心(细胞生物学、分子生物学和生物分析)的助理核心主任 加强科学指导、核心管理和用户基础；(2)获得三大工具(一个超级 用于尼康A1R共焦显微镜的高分辨率尼康STEDYCON组件，一台Bruker TimsTOF Pro2 LC-质谱仪系统和Pavine纳米压痕仪)，以扩大研究能力和专业知识 超高分辨率成像、蛋白质组学和生物材料的机械变形性-所有这些都是中央 与CIBBR调查人员、UNH和外部研究界的相关性；(3)提供用户培训， 讲习班和支持(与CIBBR数据科学核心一起)，以鼓励和促进使用 现代仪器和技术，扩大用户基础，确保科学严谨和 可重复性；(4)制定和实施业务计划，提高工具利用率并整合 MCP研究核心的基础设施可持续性机制。 在完成上述目标后，MCP核心将拥有先进的能力、专业知识、 UNH CIBBR可用的生物医学研究基础设施的用户基础、管理和可持续性 和地区性研究人员。MCP核心还将为CIBBR调查人员提供前进的机会 他们的研究计划，同时获得新的技能和知识，以增强CIBBR的影响力和 可持续发展。总而言之，这将提高CIBBR支持的研究项目和其他项目的生产率 MCP核心用户，同时有效促进科研知识的转化，增进人类健康。

PROJECT SUMMARY (MOLECULAR AND CELLULAR PHENOTYPING CORE) As a major research core component of UNH’s COBRE: Center of Integrated Biomedical and Bioengineering Research (CIBBR), the overall goal of the Molecular and Cellular Phenotyping (MCP) Core is to enable new technologies that translates rigorous multidisciplinary research into biomedical and bioengineering solutions while judiciously managing the MCP Core research infrastructure to ensure long-term sustainability. The Phase 2 objectives are to: (1) Appoint CIBBR faculty with the appropriate expertise to serve as Assistant Core Directors to the three MCP sub-cores (Cellular Biology, Molecular Biology, and BioAnalytics) to boost scientific guidance, core management, and user bases; (2) Acquire three major instruments (a super- high resolution Nikon STEDYCON module for the Nikon A1R confocal microscope, a Bruker timsTOF Pro2 LC-mass spectrometer system, and a Pavine nanoindenter) to expand research capacity and expertise in super-high resolution imaging, proteomics, and the mechano-deformability of biomaterials—all of central relevance to CIBBR investigators and the UNH and external research community; (3) Provide user training, workshops and support (in conjunction with the CIBBR Data Science Core) to encourage and enable the use of contemporary instrumentation and techniques, expand user bases, and ensure scientific rigor and reproducibility; (4) evolve and implement a business plan increases instrument utilization and integrates mechanisms for infrastructure sustainability of the MCP Research Core. Upon completion of the above objectives, the MCP Core will have advanced the capabilities, expertise, user base, management, and sustainability of the biomedical research infrastructure available to CIBBR, UNH and regional researchers. The MCP Core will also provide opportunities for CIBBR investigators to advance their research programs, while acquiring new skills and knowledge that bolster CIBBR’s impact and sustainability. Together, this will heighten the productivity of CIBBR-supported research programs and other MCP Core users, while effectively promoting the translation of research knowledge to enhance human health.