Molecular & Developmental Biology in Pediatric Research

描述（由申请人提供）：西奈山医学院的儿童健康研究职业发展奖（CHRCDA）项目旨在提供2-3年的指导，强化基础研究经验，为儿科医生在生物医学研究和学术儿科方面的独立职业生涯做好准备。这项提案的主题是“儿科的分子和发育生物学”，它与儿童时期最常见的疾病有着独特的相关性。它包括正常的发育生物学以及胎儿和儿童在个体发生过程中对侮辱的适应。该计划的多学科性质-从儿科，人类遗传学，内科，分子，细胞和发育生物学，免疫生物学，药理学和生物化学，生理学和生物物理学等部门的知名科学家的经验中汲取-已经从共同的兴趣，频繁的互动，儿科科学家过去的培训以及教师正在进行的几个领域的合作研究中发展而来。该项目将通过与中心教师的合作，通过新项目开发奖励提供的启动资金，以及通过项目的教育核心，为年轻的儿科科学家提供严格而灵活的基础研究经验。项目执行委员会对新项目发展学者的选择将是高度竞争的，只有那些具有特殊证书或潜力的个人才会被项目执行委员会接受。将实施一项新策略，招募代表性不足的少数民族加入该计划。将为每位学者准备一份职业规划，该规划将考虑具体的长期和短期研究职业目标以及有助于作为独立研究者发展的能力。该项目在儿科系和基础科学系的教师实验室将作为儿科研究人员发展的场所。CHRCDA项目将利用西奈山医学院的共享核心实验室，如最先进的细胞和全动物成像方法，转基因和敲除小鼠模型的生产，以及高通量基因筛选和基因表达谱。所有CHRCDA学者都将参加旨在加强他们的指导项目的教学会议。定期的研究研讨会和定期的实验室研讨会也将促进年轻研究者和项目教师之间的互动。总的来说，该项目得到了集中的实验室设施和教师，机构内研究项目之间的现有互动，许多核心实验室资源可供研究人员随时使用，以及高素质申请人的招聘基地已经被西奈山临床部门和基础科学的卓越所吸引。

DESCRIPTION (provided by applicant): The Child Health Research Career Development Award (CHRCDA) Program at the Mount Sinai School of Medicine is designed to provide mentored, intensive basic research experience for a period of 2-3 years necessary to prepare pediatricians for productive and independent careers in biomedical research and academic pediatrics. The theme of this proposal, "Molecular and Developmental Biology in Pediatrics," has unique relevance to the most common disorders seen in childhood. It encompasses normal developmental biology as well as adaptation of the fetus and child to insults occurring during ontogenesis. The multidisciplinary nature of the program - drawing from the experience of established scientists in the Department of Pediatrics, Human Genetics, Internal Medicine, Molecular, Cellular and Developmental Biology, Immunobiology, Pharmacology and Biological Chemistry, and Physiology and Biophysics - has evolved from common interests, frequent interactions, past training of pediatric scientists, and several areas of ongoing collaborative research of the faculty. The program will provide rigorous and flexible basic research experience for young pediatric scientists through collegial interaction with Center faculty, through startup funding as provided by new project development awards, and through the program's educational core. The selection of new project development scholars by the Program Executive Committee will be highly competitive and only those individuals with exceptional credentials or potential will be accepted by the program's Executive Committee. A novel strategy to recruit under-represented minorities to the program will be implemented. A career plan will be prepared for each scholar that will consider specific long and short-term research career goals and the competencies that will contribute to development as an independent investigator. The laboratories of the program's faculty in the Department of Pediatrics and in basic science departments will serve as sites for pediatric research faculty development. The CHRCDA program will utilize the Shared Core Laboratories at Mount Sinai School of Medicine such as state of the art methodology for cell and whole animal imaging, for production of transgenic and knockout mouse models, and for high throughput gene screening and gene expression profiling. All CHRCDA scholars will participate in didactic sessions designed to enhance their mentored program. Regular research seminars and periodic laboratory workshops will also promote interactions among young investigators and program faculty. Overall, the program is enhanced by centralization of laboratory facilities and faculty, the existing interactions amongst research programs within the institution, the many core laboratory resources which are readily available to researchers, and the recruitment base of highly qualified applicants already attracted to the excellence of Mount Sinai's clinical departments and basic sciences.