Pediatric Center for Gene Expression and Development

描述（由申请人提供）：本申请是为我们的儿童健康研究职业发展奖（CHRCDA），这已经建立了一个卓越的基础和临床研究培训在儿科增强独特的中心继续资助重点是分子和细胞生物学和临床科学。这是该补助金的第三次续期。我们的CHRCDA已经支持了我们机构的32位学者，其中许多人已经成为学术儿科学的国家领导人。总的来说，我们的学者发表了约644篇论文，并获得了超过5000万美元的资助（包括28个R 01）。该中心加强了年轻儿科教师的学术生涯发展，提供指导和核心设施，旨在加强儿科医生的培训，为学术生涯所需。该中心被整合到创新的研究培训计划中，包括Procter Scholar计划和广泛的NIH资助的研究计划。该计划确定并招募有前途的年轻儿科教师，他们在CHRCDA计划内完成2- 3年的研究增强计划，该计划由资深科学家导师组成，他们在分子细胞生物学，分子医学或临床科学方面有共同的中心重点。职业发展包括：1）中心工作人员研究人员的个人指导; 2）分子遗传学，发育生物学，临床研究，流行病学和转化研究的正式和非正式培训;和3）核心研究要素，优先考虑不同研究方法的培训，包括分子生物学，免疫学，基因组学和转基因/基因靶向模型。目前的提案已经吸引了儿童医院和辛辛那提大学医学院在发展科学方面具有卓越成就的研究人员。为了实现我们的培训目标，提出了一个由四部分组成的中心：1）中心工作人员研究人员谁分享的兴趣和专业知识，在分子和细胞生物学和信息技术在哺乳动物发育，分子医学和临床研究的研究中的应用，作为儿科医生学者的主要导师。2)行政核心确定招聘和监测儿科医生学者的整体培训。核心小组在地方和国家两级为国家征聘工作提供支助，并优先考虑少数族裔的征聘工作。3)研究核心促进分子和细胞生物学，临床研究/流行病学和统计学的儿科医生学者的研究计划的应用。4)研究支持赠款为儿科医生学者提供为期2-3年的研究资金和指导。这种在当代分子，细胞，发育生物学和临床科学的个人指导和高级培训相结合的计划，提高了我们的医生学者的培训和研究生产力，因为他们开始在儿科科学的高产学术生涯。

DESCRIPTION (provided by applicant): This application is for continued funding for our Child Health Research Career Development Award (CHRCDA), which has established a unique center of excellence for the enhancement of basic and clinical research training in pediatrics with focus on molecular and cellular biology and clinical sciences. This is the third renewal of this grant. Our CHRCDA has supported 32 scholars at our institution, many of whom have become national leaders in academic pediatrics. Collectively, our scholars have published ~644 papers and obtained over $50 million in grant dollars of funding (including 28 R01's). The Center enhances academic career development of young pediatric faculty, providing mentorship and Core facilities designed to enhance the training of pediatricians as required for an academic career. The Center is integrated into innovative established programs for research training including the Procter Scholar Program and extensive NIH funded research programs. The program identifies and recruits promising young pediatric faculty who complete a 2- 3 year program for research enhancement within a CHRCDA program comprised of senior scientist mentors who share a central focus in molecular-cellular biology, molecular medicine or clinical sciences. Career development includes: 1) individual mentorship by Center staff investigators; 2) formal and informal training in molecular genetics, developmental biology, clinical research, epidemiology, and translational research; and 3) Core research elements which prioritizes training in diverse research approaches including molecular biology, immunology, genomics and transgenic/gene targeting models. The present proposal has drawn together established investigators with excellence in developmental science at the Children's Hospital and the University of Cincinnati College of Medicine. To meet our training goals, a four-part Center is proposed: 1) Center staff investigators who share interest and expertise in the application of molecular and cellular biology and informatics technology in the study of mammalian development, molecular medicine, and clinical research serve as primary mentors for the pediatrician-scholars. 2) Administrative Core identifies recruits and monitors the overall training of pediatrician-scholars. The Core provides support for national recruitment efforts, at local and national levels and prioritizes minority recruitment. 3) Research Cores facilitate the application of molecular and cellular biology, clinical research/epidemiology and statistics to the research programs of pediatrician-scholars. 4) Research support grants provide the pediatrician-scholar research funds and mentorship for a period of 2-3 years. This combined program of individual mentorship and advanced training in contemporary molecular, cellular, developmental biology, and clinical sciences enhances the training and research productivity of our physician-scholars as they begin highly productive academic careers in pediatric science.