Role of mechanical stress in mitigating chemotherapy-associated bone loss

项目摘要/摘要 基质生物学卓越生物医学研究中心行政补充将 支持理想状态下的妇女健康研究，特别是爱达荷州。这项研究的结果 将加强我们对乳腺癌如何维持骨骼健康的理解 幸存者和那些接受过化疗的人。这个问题是 对接受过乳腺癌治疗的妇女的担忧，因此她们正处于 增加骨质疏松和骨折的风险。罹患乳腺癌的风险随着 年龄，在60岁及以上的妇女中尤其高。因为她们的年龄，这些女人是 患骨质疏松症的风险已经增加。爱达荷州的病例比率高于全国 平均水平，在爱达荷州一些更农村的县要高得多。预防和 需要进行治疗干预，以最大限度地减少骨丢失，降低骨折风险 以及不断增长的人口。拟议的工作将利用博伊西州立大学的现有资源 大学，特别是生物分子研究核心和RNA测序实验室。 这个项目的目标是研究低强度振动引起的改善 间充质干细胞的DNA损伤修复，成骨细胞分化，以及 顺铂治疗过程中细胞外基质的产生。这个项目的结果将产生一个 更好地理解外力是如何参与维持骨骼健康的 在抗癌治疗期间。在建议的实验完成后，我们预计会有 更好地了解非药物和有针对性的治疗干预措施以减少 化疗后的长期后遗症。拟议工作的结果可能会减少骨骼 骨折、癌症转移和复发。此外，本行政副刊将 扩大研究能力，开展国家妇女健康研究 爱达荷州。

PROJECT SUMMARY/ABSTRACT The Center of Biomedical Research Excellence in Matrix Biology administrative supplement will support women’s health research in an IDeA state, specifically Idaho. The results of this study will enhance our understanding of how bone health may be maintained for breast cancer survivors and those who have undergone chemotherapy. This question is at the foundation of concerns for women who have had breast cancer treatment and who are therefore at an increased risk for osteoporosis and fracture. The risk of developing breast cancer increases with age and is particularly high in women age 60 and older. Because of their age, these women are already at an increased risk for osteoporosis. Case rates in Idaho are higher than the national average, and much higher for some of the more rural counties within Idaho. Prevention and therapeutic interventions are needed to minimize bone loss and reduce fracture risk in this large and growing population. The proposed work will leverage resources available at Boise State University, specifically the Biomolecular Research Core and the RNA sequencing laboratory. The objective for this project is to investigate low-intensity vibration-induced improvements in both DNA damage repair in mesenchymal stem cells, osteoblast differentiation, and extracellular matrix production during cisplatin treatment. Results from this project will yield a greater understanding of how external mechanical force is involved in maintaining bone health during anti-cancer treatment. At the completion of the proposed experiments, we anticipate a greater understanding of non-pharmacologic and targeted therapeutic interventions to decrease long-term sequelae following chemotherapy. The results of the proposed work may reduce bone fractures, cancer metastasis, and recurrence. Additionally, this administrative supplement will expand the research and research capacity to conduct women’s health research in the state of Idaho.