Translational Research in Neurobiolgy of Disease Training Program

描述（由申请人提供）：本申请申请明尼苏达大学“疾病神经生物学转化研究”培训资助。该计划的受训者包括：1)通过神经科学研究生计划攻读博士学位的研究生；2)博士后研究员；3)临床研究员。我们面临的挑战是，如何培养对临床相关问题有鉴赏力的基础神经科学家，以及培养对基础科学工具的基本原理有鉴赏力的临床医生，以便他们能够共同努力，加快转化神经科学的步伐。拟议的培训计划资助博士生在神经科学研究生课程的第二年，在他们致力于转化神经科学的轨道。博士后和临床研究员可以在培训的任何阶段获得资助，但必须致力于转化神经科学的培训。培训项目以教学课程为核心，包括疾病神经生物学课程和面向所有受训者的神经科学实验室暑期课程。这些课程旨在促进基础和临床神经科学家之间的对话和互动，以促进转化研究。一个超过37名培训师的小组被提议，反映了基础和临床神经科学研究技术的多样性，但主题集中在神经退化和修复。研究兴趣范围从神经退行性疾病的分子机制到涉及干细胞和重组DNA的治疗。每个培训师指导一个富有成效的研究项目，并表现出对教学和培训的承诺。这些培训师代表了整个大学的11个系，他们通过参与神经科学和转化神经科学研究的研究生课程而团结在一起。学员将在基础和临床神经科学方面打下坚实而广泛的基础，在此基础上建立他们的转化研究事业。

DESCRIPTION (provided by applicant): This proposal is for a training grant, "Translational Research in Neurobiology of Disease", at the University of Minnesota. Trainees of this program are 1) graduate students who are pursuing a Ph.D. degree through the Graduate Program in Neuroscience, 2) postdoctoral fellows, and 3) clinical fellows. The challenge is to train basic neuroscientists who will have an appreciation for clinically relevant problems, and to train clinicians who have an appreciation of the fundamental principals of tools of basic science so that they can work together and accelerate the pace of translational neuroscience. The proposed training program funds predoctoral students during their second year in the Graduate Program in Neuroscience after they have committed to the translational neuroscience track. Postdoctoral fellows and clinical fellows can be funded at any point in their training, but must be committed to training in translational neuroscience. The training program is built around a core of didactic course work that includes a course in Neurobiology of Disease, and a Neuroscience Laboratory summer course for all trainees. These courses are designed to produce a dialog and interactions among basic and clinical neuroscientists to facilitate translational research. A group of over 37 trainers are proposed that reflects the diversity of research techniques in basic and clinical neuroscience, but with a thematic focus on neural degeneration and repair. Research interests range from molecular mechanisms underlying neurodegenerative disorders to therapies involving stem cells and recombinant DNA. Each trainer directs a productive research program and has demonstrated commitment to teaching and training. Representing 11 departments throughout the university, the trainers are united by their participation in the Graduate Program in Neuroscience and translational neuroscience research. The trainees will be provided with a strong, broad foundation in basic and clinical neurosciences upon which to build their translational research careers.