Motion-immune magnetic resonace imaging

描述（由申请人提供）：拟议项目的长期目标是通过消除运动伪影来改善磁共振成像（MRI）期间的图像质量。MRI在扫描期间对运动高度敏感，并且运动引起的伪影的消除将基于成像身体的实时运动跟踪和跟踪数据的应用以重新对准MRI扫描仪的梯度，以便补偿运动。这项新技术可能会对医疗保健系统产生重大影响，因为在约20%的已执行研究中，运动伪影会降低图像质量，并且通常需要重复研究。此外，新的MRI模式，如功能和扩散MRI，严重影响的运动，消除运动伪影将促进其临床应用。在项目第一阶段的可行性论证之后，我们继续进入第二阶段。该项目的具体目标包括：A -将临床上用于MRI引导手术干预的FDA批准的EndoScout跟踪系统修改为可与主要类型的诊断MRI扫描仪接口的运动跟踪系统; B -使用跟踪系统提供的运动信息，通过梯度重新对齐将感兴趣的常规扫描序列修改为运动免疫序列; C -检验以下假设：通过基于运动跟踪的梯度重新对准进行运动补偿可改善研究和临床MRI中的图像质量，并且上级当前使用的运动伪影消除方法。该技术将通过罗宾医疗公司，和马萨诸塞州总医院：罗宾医疗将开发新一代的EndoScout跟踪系统，可以成为诊断MRI扫描仪的标准组件;马萨诸塞州总医院的货车der Kouwe博士将修改系统人体测试期间所需的各种研究和临床扫描序列。在通过移动体模的技术测试证明成功缓解运动伪影后，将在志愿者身上以及通过正在进行的研究和临床MRI人体研究对系统进行测试。公共卫生相关性：所提出的运动伪影减轻技术可以降低与重复MRI扫描的常见需要相关联的医疗保健成本，所述MRI扫描被患者运动损害。此外，由于许多诊断性MRI扫描因运动而退化，但由于MRI的高成本而无法重复，因此新技术可以通过提供更高质量的图像来提高MRI的诊断率。此外，运动免疫序列可用于儿科患者，并减少该人群中某些年龄组的麻醉需求。

DESCRIPTION (provided by applicant): The long term aims of the proposed project are to improve image quality during magnetic resonance imaging (MRI) by elimination of motion artifacts. MRI is highly susceptible to motion during scan, and the elimination of the motion-induced artifacts will be based on real-time motion tracking of the imaged body and the application of the tracking data to re-align the gradients of the MRI scanner, in order to compensate for motion. This new technology can have significant impact on the health care system as motion artifacts degrade image quality in about 20% of performed studies and often require repetition of the study. Furthermore, new MRI modalities like functional and diffusion MRI are severely affected by motion, and the elimination of motion artifacts will facilitate their clinical use. Following feasibility demonstration during Phase I of the project, we continue into Phase II. The specific aims of the project include: A - To modify the FDA-cleared EndoScout tracking system that is clinically used in MRI-guided surgical interventions into a motion tracking system that can be interfaced with major types of diagnostic MRI scanners; B - To modify routine scan sequences of interest into motion-immune sequences by gradient re-alignment using motion information supplied by the tracking system; C - To test the hypothesis that motion compensation through gradient re-alignment based on motion tracking can improve image quality in research and clinical MRI and is superior to currently used methods for motion artifact elimination. The technology will be developed through a collaboration between Robin Medical, Inc., and the Massachusetts General Hospital: Robin Medical will develop a new generation of the EndoScout tracking system that can become a standard components on diagnostic MRI scanners; Dr. Van der Kouwe at the Massachusetts General Hospital will modify various research and clinical scan sequences that will be needed during human tests of the system. Following the demonstration of successful motion artifact mitigation through technical testing with moving phantom, the system will be tested on volunteers and through on going research and clinical MRI human studies. PUBLIC HEALTH RELEVANCE: The proposed motion artifact mitigation technology may reduce healthcare costs associated with the common need to repeat MRI scans that are compromised by patient motion. In addition, as many diagnostic MRI scans are degraded by motion but not repeated due to the high cost of MRI, the new technology can improve the diagnostic yield of MRI by providing higher quality images. Furthermore, the motion-immune sequences may be used with pediatric patients and reduce the need for anesthesia in some age groups of this population.