MOLECULAR IMAGING SPECIALIZED RESOURCE CORE

C2.分子成像专用资源核心（MISR）（核心#3） C2.2.1.引言：MISR的目的是支持体内分子成像要求， 拟议的NSBCC研究和其他分子成像项目在加州大学洛杉矶分校的其余部分 生物医学社区分子成像核心得到能源部（DoE）的支持， 加州大学洛杉矶分校琼森综合癌症中心核心补助金，两个SPORE赠款，加州大学洛杉矶分校-NCI小 动物分子成像（ICMIC），和几个NCI专业支持奖，除了拟议的 NSBCC。成像资源于1990年开始作为能源部设施，专门从事动物研究 断层扫描仪（Siemens，ACAT）。成像设备定期更新，采用最新成像技术 技术和技巧。1997年，加州大学洛杉矶分校开发了第一个专用的小动物microPET系统， Cherry等人将其投入常规使用，随后是CTI Concorde Microsystems的商业版本， 1999年的P4 microPET和2003年的Focus microPET。随着整体成像需求的增长， 增加了一个放射自显影系统（WBDA），一个microCAT仪器和三个光学成像系统;两个 它们具有生物发光和荧光光学成像能力。自成立以来， microPET成像实验已经成功进行。2003年，光学， microPET、microCAT和WBDA程序超过8000次实验。 MISR对于项目3中提议的工作至关重要，但它间接支持（通过ICMIC供资） 项目2和项目4中描述的工作。项目2将microPET成像系统用于小鼠癌症模型。 图像和数据分析将由定量分析核心（核心4）处理。但所有 协调专业资源（在回旋加速器和放射化学核心中制备的放射性同位素 用于MISR中的实验研究，数据存储，解释和检索由 定量分析核心）由一个名为资源分配委员会（RAC）的委员会， 地方20年，由菲尔普斯博士，NSBCC的整体合作伙伴之一主持。MISR和 定量分析核心在其日常活动中高度相互关联，以确保数据 适当地收集、处理和解释。下表总结了的预计需求 每个NSBCC项目的体内分子成像，根据拟议的项目。作为新的发展 项目和研究人员进入NSBCC，他们的需求将被纳入该设施的运作。 这个核心有足够的能力来满足NSBCC的需求，以及任何 合理扩张。

C2. MOLECULAR IMAGING SPECIALIZED RESOURCE CORE (MISR) (Core #3) C2.2.1. Introduction: The purpose of the MISR is to support the in vivo molecular imaging requirements for the proposed NSBCC research and for additional molecular imaging projects across the rest of the UCLA biomedical community. The Molecular Imaging Core receives support from the Department of Energy (DoE), the UCLA Jonsson Comprehensive Cancer Center Core Grant, two SPORE grants, the UCLA-NCI small animal molecular imaging (ICMIC), and several NCI specialized support awards, in addition to the proposed NSBCC. The Imaging Resource was started in 1990 as a DoE facility, with a dedicated animal research tomograph (Siemens, ACAT). The imaging equipment has been periodically updated with the latest imaging technology and techniques. In 1997, the first dedicated small animal microPET system developed at UCLA by Cherry et al. was put into routine use, followed by commercial versions from CTI Concorde Microsystems, the P4 microPET in 1999 and the Focus microPET in 2003. As overall imaging demand grew, a whole body digital autoradiography system (WBDA), a microCAT instrument and three optical imaging systems were added; two of which have both bioluminescent and fluorescent optical imaging capabilities. Since inception, over 13,000 microPET imaging experiments have been successfully conducted. In 2003, the combined number of optical, microPET, microCAT and WBDA procedures exceeded 8000 experiments. The MISR is essential for the work proposed in Project 3, but it indirectly supports (through ICMIC funding) work described in Projects 2 and 4. Project 2 utilizes microPET imaging systems for mouse models of cancer. Image and data analysis will be handled by the Quantitative Analysis Core (Core 4). However, all the Specialized Resources are coordinated (radioisotopes prepared in the Cyclotron and Radiochemistry Core used for experimental studies in the MISR, data storage, interpretation and retrieval facilitated by the Quantitative Analysis Core) by a committee called the Resource Allocation Committee (RAC) that has been in place for 20 years and is chaired by Dr. Phelps, one of the overall Co-Pis of NSBCC. The MISR and the Quantitative Analysis Cores are highly inter-linked in their day-to-day activities to ensure that data are collected, processed and interpreted appropriately. The following table summarizes the projected needs of each NSBCC project for in vivo molecular imaging, based on the proposed Projects. As new developmental projects and researchers enter the NSBCC, their needs will be incorporated into the operations of the facility. This core has more than enough capacity to meet the needs of NSBCC as proposed, as well as any reasonable expansion.