Does social motivation in adolescence differentially predict the impact of childhood threat exposure on developing suicidal thoughts and behaviors

项目总结 本次K23以患者为导向的研究事业发展奖的目标是为候选人 获得儿童威胁暴露、社会动机(SM)和自杀念头风险方面的专业知识 行为(STB)。儿童期接触威胁会影响大脑功能，从而增加性传播疾病的风险 人际关系紧张。青春期充满了人际压力；然而，并不是所有的青少年都有童年 威胁暴露经历了性传播疾病，表明其他因素会加剧风险。确定其他 与性传播疾病增加威胁相互作用的因素对于确定新的自杀预防目标是必不可少的 机械装置。该项目将确定SM是否代表调节链接的额外因素 儿童时期的威胁暴露和性传播疾病之间的关系。该奖项的培训目标将包括在以下方面获得技能： (1)儿童威胁暴露和SM的发展心理病理学模型；(2)神经生物学和SM STBS风险的行为机制，以及(3)高级脑密集时间序列建模 连通性。培训将促进进行自我报告、大脑和行为特征的研究的能力 青少年SM测量(目标1)--考察不适应的社会动机是否加强了这种联系 在威胁暴露和性传播疾病之间(目标2)。最后的探索性目标3将允许进行初步调查 探讨青春期、生物性别和年龄如何进一步调节威胁暴露和SM之间的交互作用 STBS。这项研究将利用两个R01项目在两个队列中测试AIMS；队列1(n=220)包括早期 9-16岁的青春期女性，而队列2(n=275)由15-15岁的青少年男性和女性组成。 18.来自北卡罗来纳大学教堂山分校、华盛顿大学圣路易斯分校和 伊利诺伊大学厄巴纳-香槟分校将指导和咨询候选人的3个培训目标 本项目：玛格丽特·谢里登博士和亚当·米勒博士(共同的主要导师)，以及凯伦·鲁道夫 博士，迪安娜·巴克博士，凯蒂·盖茨博士(科学顾问)，伊娃·特尔泽博士和琼·卢比， 医学博士(咨询师)。该奖项提供了必要的培训，以成为一个独特的，跨学科的 临床、社会和发育神经科学交叉领域的研究人员。在与 导师，候选人将使用培训和研究结果来指导下一步的工作 儿童时期的逆境、社会动机和性传播疾病风险的候选人研究计划 青春期。此奖项的培训和结果也将通知未来的R01提交。

PROJECT SUMMARY This goal of this K23 Mentored Patient-Oriented Research Career Development Award is for the candidate to gain expertise in childhood threat exposure, social motivation (SM), and risk for suicidal thoughts and behaviors (STBs). Childhood threat exposure increases risk for STBs by affecting brain functioning associated interpersonal stress. Adolescence is filled with interpersonal stress; yet, not all adolescents with childhood threat exposure experience STBs, indicating that additional factors exacerbate risk. Identifying additional factors that interact with threat to increase STBs is imperative for identifying novel suicide prevention target mechanisms. This project will identify whether SM represents an additional factor that moderates the link between childhood threat exposure and STBs. Training objectives for this award will include skill acquisition in: (1) Developmental psychopathology models of childhood threat exposure and SM, (2) Neurobiological and behavioral mechanisms of risk for STBs, and (3) Advanced intensive time series modeling of brain connectivity. Training will facilitate the ability to conduct a study characterizing self-report, brain, and behavioral measures of SM in adolescents (Aim 1) to examine whether maladaptive social motivation strengthens the link between threat exposure and STBs (Aim 2). A final exploratory Aim 3 will allow for a preliminary investigation into how puberty, biological sex, and age further moderate the interaction between threat exposure and SM on STBs. This study will leverage two R01 projects to test Aims in two Cohorts; Cohort 1 (n = 220) includes early adolescent females aged 9 – 16, while Cohort 2 (n = 275) consists of adolescent male and females aged 15- 18. Experts from the University of North Carolina at Chapel Hill, Washington University St. Louis, and the University of Illinois Urbana-Champaign will mentor and consult with the candidate on the 3 training goals of this project: Margaret Sheridan Ph.D. & Adam Miller Ph.D. (Co-primary mentors), along with Karen Rudolph Ph.D., Deanna Barch Ph.D., Katie Gates, Ph.D. (Scientific Advisors), and Eva Telzer, Ph.D. and Joan Luby, M.D. (Consultants). This award provides the necessary training to become a unique, transdisciplinary researcher at the intersection of clinical, social, and developmental neuroscience. In consultation with the mentors, the candidate will use the training and the results of the research to inform the next steps in the candidate’s program of research on childhood adversity, social motivation, and risk for STBs during adolescence. Training and results from this award will also inform future R01 submission.