Systems Biology Core

这个翻译研究中心（CORT）应用程序的主题是牛皮癣。这个目标 牛皮癣的治疗方法有哪些？牛皮癣的治疗方法有哪些 牛皮癣的治疗方法有哪些？牛皮癣的治疗方法有哪些？因此，我们包括 系统生物学核心（SBC），旨在支持这里描述的各个RO 1项目。 SBC将提供各种有针对性的服务，以提高皮肤相关的科学质量。 调查人员的调查。SBC是一个综合性的分子生物学实验室，专注于高 通量基因发现和分析，包括分子遗传学、基因组学和蛋白质组学 技术以及相关的生物信息学和信息管理。 SBC将提供最先进的分子生物学技术服务，培训和咨询 技术，如RNA和蛋白质提取小组织活检，激光捕获显微镜，真实的- 时间PCR定量核酸、微阵列和蛋白质组学技术以及生物信息学支持 用于管理、分析、显示和整合基因组学和蛋白质组学数据。 博士Karnik的实验室构成了系统生物学核心实验室的骨干， 包括”！位于生物医学研究大楼5楼的研究区面积为1，000平方英尺。是 配备细胞和分子生物学研究，一个区域指定为RNA工作和一个复杂的 微阵列和蛋白质组学数据简化、数据挖掘和途径分析的计算机系统。SBC 将与机构蛋白质组学和基因组学核心以及 SDRC核心和Psouth地区临床网络的Murdough家庭中心，以促进 CORT研究人员的研究。所有设施都在步行五分钟内与相邻的建筑相连 一座室内桥。总之，系统生物学核心主任和顾问有广泛的 具有核心提出的技术和服务的经验，将成为CORT的巨大财富 拟议的RO 1项目以及未来的P&F项目。SBC将支持所有提议的项目 在CORT中，因此是成功的关键资源。

The theme of this Center of Research Translation (CORT) application is psoriasis. The goal of this multidisciplinary effort is to better understand the pathophysiology of psoriasis, to test therapeutic interventions for psoriasis, and to develop new technologies for treatment of psoriasis. Therefore we include the Systems Biology Core (SBC), designed to support the individual RO1 projects described here. The SBC will provide a variety of services that are targeted to enhance the scientific quality of skin-related research to CORT investigators. The SBC is an integrated molecular biology laboratory focusing on high- throughput gene discovery and analysis, including molecular genetics, genomics and proteomics technologies together with associated bioinformatics and information management. The SBC will provide technological services, training and consultation in state of the art molecular biology technologies such as RNA and protein extraction from small tissue biopsies, laser capture microscopy, real- time PCR quantification of nucleic acids, microarray and proteomics technology and bioinformatics support for management, analysis, display and integration of genomic and proteomics data. Dr. Karnik's laboratory constitutes the backbone of the Systems Biology Core laboratory and will include"! ,000 square feet of research area located on the 5th floor of the Biomedical Research Building. It is equipped for cell and molecular biology studies, an area designated for RNA work and a sophisticated computer system for microarray and proteomics data reduction, data mining and pathway analysis.The SBC will complement and interdigitate with the institutional proteomics and genomics cores as well as with the SDRC cores and the Murdough Family Center of Psoriasis' Regional Clinical Network to facilitate the research of CORT investigators. All facilities are within a five-minute walk in adjacent buildings connected by an indoor bridge. Together, the Systems Biology Core director and consultants have extensive experience with the techniques and services proposed by the Core and will be a great asset to the CORT RO1 projects proposed, as well as to future P&F projects. The SBC will support all of the projects proposed in the CORT and is thus a key resource for success for the Case Psoriasis CORT.