ENDOCRINE PANCREATIC FUNCTION IN RECIPIENTS OF PANCREAS ISLET TX

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的总体目标是描述人类胰腺移植和半胰脏捐献的长期代谢影响。这个正在进行的项目将纵向评估胰腺和胰岛移植以及半胰腺切除对葡萄糖耐量、胰岛素分泌和胰岛素作用的影响。此外，还将检查半胰腺切除供者的胰岛素脉动分泌模式。这些信息将有益于目前和未来的胰腺和胰岛移植受者，并将为神经和内分泌调节剂在调节胰腺功能和葡萄糖稳态中的作用提供深入的见解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this investigation is to characterize the long-term metabolic effects of pancreas transplantation and hemipancreas donation in humans. This on-going project will longitudinally assess the effects of pancreas and islet transplantation and hemipancreatectomy on glucose tolerance, insulin secretion, and insulin action. In addition, the pattern of pulsatile insulin secretion will be examined in hemipancreatectomized donors. This information will be of benefit to current and future pancreas and islet transplant recipients and will provide insights into the role of neural and endocrine modulators in the regulation of pancreatic function and glucose homeostasis.