TESTOSTERONE DOSE RESPONSE IN SURGICALLY MENOPAUSAL WOMEN

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 正常情况下，女性即使在绝经后也会在卵巢中产生睾丸激素。通过手术切除双侧卵巢的女性通常睾丸激素水平较低，这可能导致性功能，肌肉功能和一般健康感下降。这项研究的目的是确定什么是最合适的剂量的睾酮是给妇女谁有他们的卵巢切除前绝经期和低睾酮水平在他们的血液。睾酮的最适当剂量将是睾酮的量，最大限度地提高了有益的效果，同时最大限度地减少副作用.我们将随机分配140名年龄在21岁至60岁之间的女性，她们已经切除了卵巢，分为四组，每周注射安慰剂或三种剂量的睾酮，为期6个月（双盲）。受试者在研究期间还将接受雌激素贴剂治疗。睾酮的作用将通过测量瘦身体组织，肌肉大小，肌肉力量和腿部力量，性功能和大脑功能来确定。我们还将测量血浆脂质（血液中的胆固醇和胰岛素敏感性的一些功能（身体如何处理糖）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Normally women produce testosterone in their ovaries even after menopause. Women who have had both ovaries removed by surgery usually have low testosterone levels which may contribute to reduced sexual function, muscle function and general sense of well being. The purpose of this study is to determine what the most appropriate dose of testosterone is to give to women who have had their ovaries removed before menopause and have low testosterone levels in their blood. The most appropriate dose of testosterone will be the amount of testosterone that maximizes the beneficial effects while minimizing side effects. We will do this by randomly assigning 140 women between the ages of 21 and 60 who have had their ovaries removed to four groups which receive either placebo or one of three doses of testosterone by weekly injections for 6 months (double blind.) Subjects will also be treated with an estrogen patch during the study. The effects of testosterone will be determined by measuring lean body tissue, muscle size, muscle strength and leg power, sexual function and brain function. We will also measure plasma lippids (cholesterol in the blood and some functions of insulin sensitivity (how the body handles sugar).