MEASUREMENT OF TEMPORAL CHANGES IN NEUROTRANSMITTER LEVELS VIA PET

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 这个项目的目标是双重的。 第一步是创建适当的数学框架，通过该数学框架，可以使用受体配体的PET研究来重建响应于认知或药理学刺激而发生的内源性神经递质释放的时间模式。 一旦建立了数学分析技术，我们将把它们应用于PET数据采集在健康的正常对照组和重度（但依赖）酒精消费者的酗酒风险。 有人建议，由于乙醇渴望（由酒精相关的线索诱导）释放的多巴胺的模式将在这些受试者人群之间是不同的。 这项试点研究将允许开发一种新的技术，在神经影像学，并将收集初步的数据，可能的神经生物学基板的酒精中毒和药物滥用，迄今尚未在体内检查。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is twofold. The first step is to create the proper mathematical framework by which PET studies with receptor ligands can be used to reconstruct temporal patterns of endogenous neurotransmitter release that occur in response to cognitive or pharmacological stimulation. Once the mathematical analysis techniques have been established, we will apply them to PET data acquired in both healthy normal control subjects and heavy (but dependent) ethanol consumers at risk for alcoholism. It is proposed that the pattern of dopamine released as a result of ethanol craving (induced by alcohol-related cues) will be different between these subject populations. This pilot study will allow development of a novel technique in neuroimaging and will collect preliminary data on possible neurobiological substrates of alcoholism and drug abuse not heretofore examined in vivo.