DEVELOPING A PARADIGM TO DETECT SENSITIVITY TO THE RATE OF CHANGE OF BRAC

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们的实验室专门研究大脑暴露于酒精的时间过程。 我们已经证明，人类大脑对酒精的浓度和大脑暴露于酒精开始后的时间都有反应（对酒精的急性适应）。 这个项目开始了我们对大脑对酒精时间变化率的反应的研究。 在这个初步的发展研究中，我们寻求最佳组合的多段，恒定斜率处方的BrAC用于最终的科学研究，并构建一个电池的依赖措施的脑功能，可以测量非常频繁，因为BrAC将在整个实验中迅速变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our lab specializes in prescribing the time course of brain exposure to alcohol. We have demonstrated that the human brain responds to both the concentration of alcohol and the time since exposure of the brain to alcohol began (acute adaptation to alcohol). This project begins our study of the brain's response to the rate of change with respect to time of alcohol. In this preliminary developmental study, we seek the optimum combination of multi-segment, constant slope prescriptions for the BrAC to be used in an eventual scientific study, and to construct a battery of dependent measures of brain function that can be measured very frequently, since BrAC will be changing rapidly throughout the experiment.