NOCTURNAL SECRETION OF OVARIAN STEROIDS, LH, AND FSH IN ADOLESCENT GIRLS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 青少年高雄激素血症似乎是多囊卵巢综合征(PCOS)的先兆。多囊卵巢综合征患者对孕激素抑制GnRH搏动性的敏感性降低，这可能是由于雄激素水平升高所致，因为GnRH的敏感性可以通过雄激素受体阻断恢复正常。我们的目标是研究青春期有或没有雄激素升高的青春期女孩夜间卵巢类固醇、黄体生成素和卵泡刺激素的分泌模式。这一结果将加深我们对多囊卵巢综合征病因的认识。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Adolescent hyperandrogenemia appears to be a precursor to polycystic ovary syndrome (PCOS). Women with PCOS have a reduced sensitivity to progesterone inhibition of GnRH pulsatility, likely due to elevated levels of androgens, as GnRH sensitivity can be restored to normal by androgen receptor blockade. We aim to examine the nocturnal secretory patterns of ovarian steroids, LH, & FSH in adolescent girls with or without elevated androgens during puberty. The results will advance our knowledge of the causes of PCOS.