MECHANISMS OF EXERCISE INTOLERANCE AND EFFECTS OF TRAINING IN CHILDREN WITH H

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标#1：比较慢性心脏病儿童和健康儿童的体力活动水平和久坐行为。 具体目标2：评估运动耐量与中枢(心肺功能)和外周(骨骼肌、儿茶酚胺和细胞因子反应)机制的关系。 具体目标#3：评估短期运动训练对心肺容量、肌肉体积、儿茶酚胺和细胞因子对运动和生活质量措施的反应的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aim #1: To compare the physical activity level and sedentary behavior of children with chronic cardiac conditions to that of healthy children. Specific Aim #2: To evaluate the physical activity level in relation to central (cardiopulmonary function) and peripheral (skeletal muscle and catecholamine and cytokine responses) mechanisms of exercise intolerance. Specific Aim #3: To assess the effect of short-term exercise training on cardiopulmonary capacity, muscle volume, catecholamine and cytokine responses to exercise and quality of life measures.