PACTG 390

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 本研究的主要目的是：比较2种NRTI+一种蛋白酶抑制剂（PI）与2种核苷逆转录酶（NRTI）+一种非核苷逆转录酶抑制剂（NNRTI）联合治疗作为初始治疗，如果失败，则进行二线治疗，就其对长期病毒学终点的影响而言，并比较从一线转为二线的两种不同病毒载量标准-线治疗艾滋病毒抗逆转录病毒初治儿童> 30天和< 18岁。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objectives of this study are: to compare the combination of 2 NRTIs plus a protease inhibitor (PI) versus 2 Nucleoside Reverse Transcriptase (NRTIs) plus a non-nucleoside reverse transcriptase inhibitor (NNRTI) as initial therapy, followed by second-line therapy if failure occurs, in terms of their effects on a long-term virologic endpoint and to compare two different viral load criteria for switching from first-line to second-line therapy in HIV Antiretroviral Naive Children > 30 Days and < 18 years of age.