EARLY DETECTION OF GESTATIONAL DIABETES BY METABOLOMICS AND PROTEOMICS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是了解为什么一些孕妇在怀孕期间和怀孕后会出现高血糖。这种情况被称为胰岛素抵抗，它可能与成年后患糖尿病的风险有关。我们计划在葡萄糖耐量试验中测量胰岛素抵抗的程度和胰岛素分泌，在试验中受试者将接受一种特殊的葡萄糖混合物。我们将把这种测量与一些不同的代谢标记物联系起来。我们认为，这些标记物可能有助于确定胰岛素抵抗的个体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to understand why some pregnant women develop high blood sugars during and after pregnancy. This condition is called insulin resistance and it may be associated with the risk of developing diabetes mellitus as an adult. We plan to measure the degree of insulin resisitance and insulin secretion during a glucose tolerance test in which the subject will receive a special mixture of glucose. We are going to relate that measurement to a number of different metabolic markers. We think that the markers may help determine individuals who are insulin resistant.