VASCULAR FUNCTION IN CHILDREN WITH OSA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 儿童睡眠呼吸障碍综合征包括单纯性打鼾、阻塞性通气不足和不同程度的阻塞性睡眠呼吸暂停。该综合征发生在超过12%的儿童中，大多数有轻度至中度的参与。如果不了解严重程度较低的SDB的长期心血管发病率，则无法评估患有该疾病的儿童的适当管理和成年期心血管疾病的预防。我们推测，在SDB儿童中，全身炎症细胞因子和急性期反应物水平的升高与疾病的严重程度以及血管和心肌重塑相关。我们已经报道了SDB儿童的左心室改变与高血压和肥胖无关。左心室重构的机制尚不清楚。我们的数据表明，在SDB儿童中，急性期反应物的血浆水平与左心室质量之间存在很强的相关性。类似地，血浆细胞因子水平与颈动脉内膜厚度相关。 本研究的目的有三个：1）比较5- 13岁不同程度SDB儿童与正常对照儿童的炎症性心血管疾病机制; 2）确定血浆中细胞因子水平与扁桃体中细胞因子水平的关系; 3）检测炎症标志物与颈动脉内膜厚度、颈动脉顺应性、脉压、主动脉僵硬度和左心室质量及功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The pediatric syndrome of sleep disordered breathing encompasses children with simple snoring, obstructive hypoventilation and varying degrees of obstructive sleep apnea. The syndrome occurs in more than 12% of children, with most having mild to moderate involvement. Without knowledge of the long-term cardiovascular morbidity with less severe forms of SDB, adequate management of children with the disorder and prevention of cardiovascular disease during adulthood cannot be assessed. We hypothesize that in children with SDB, increased systemic levels of inflammatory cytokines and acute phase reactants correlate with severity of the disorder and with vascular and myocardial remodeling. We have reported left ventricular changes in children with SDB occurring independently of hypertension and obesity. The mechanism of left ventricular remodeling remains undefined. Our data show that in children with SDB there is a strong association between plasma levels of acute phase reactants and left ventricular mass. Similarly, levels of plasma cytokines correlate with carotid artery intima thickness. The goals of this study are threefold: 1) to compare inflammatory cardiovascular disease mechanisms in 5- to 13-year-old children with varying degrees of SDB to those in normal controls; 2) to determine how cytokine levels in plasma relate to those in tonsils; 3) to examine the relationship between inflammatory markers and carotid intima thickness, carotid compliance, pulse pressure, aortic stiffness and left ventricular mass and function before and after adenotonsillectomy.