AMITRIPTYLINE IN CHILDREN WITH ABDOMINAL PAIN OF NON- ORGANIC ORIGIN

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 主要目标： 我们介入研究的主要目的是评价阿米替林对非器质性腹痛患者症状的影响。 次要目标： 研究心理社会特征(如焦虑、抑郁、疼痛应对机制、与健康相关的生活质量)与肠道症状之间的相互作用，并衡量治疗对这些变量的影响。 长期目标： 我们希望在未来通过评估这种药物或其他药物对生理变量，如内脏感觉、运动功能以及大脑成像和处理的影响来扩大该项目。 这是一项多中心、随机、双盲的安慰剂对照研究，旨在确定阿米替林在治疗功能性腹痛儿童中是否有效。研究假设将通过监测治疗阶段的日常症状以及在治疗开始前一周和一个月后进行问卷调查来验证。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary aim: The main objective of our interventional study is to evaluate the impact of the medication (amitriptyline) on symptoms of patients with abdominal pain of non-organic origin. Secondary aim: To examine the interaction between psychosocial traits (e.g., anxiety, depression, pain coping mechanisms, health-related quality of life) and bowel symptoms and measure the impact of therapy on those variables. Long term objective: We hope to expand the project in the future by evaluating this or other medications on physiologic variables such as visceral sensation, motor function and brain imaging and processing. This is a multi-center, randomized, double-blind placebo controlled study designed to determine if amitriptyline is useful in the treatment of children with functional abdominal pain. The study hypotheses will be tested by monitoring daily symptoms during the treatment phase and by administering questionnaires one week before and one month after initiation of treatment.