THE VASCULAR EFFECTS OF ACUTE HYPOXIA

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 环境或病理导致的缺氧会引起呼吸、心血管、神经和代谢功能的变化。 阻塞性睡眠呼吸暂停是一种以慢性缺氧、心血管和代谢功能障碍为特征的疾病，缺氧是其主要影响因素。 心血管控制是局部和中枢介导的，并且沿着血管树沿着是不同的。 代谢功能取决于细胞活性和血管动力学。 在人类中，缺氧已被证明会导致葡萄糖耐受不良，这是代谢功能障碍的一个指标。在大鼠中，高胰岛素血症引起微血管募集，而动脉血流没有变化。缺氧通过与胰岛素相似和不同的机制起作用，可以想象会引起动脉和微血管系统的异质性反应，导致下游代谢功能障碍。 为了测试这个问题的第一部分，我们将评估缺氧前后的动脉血流量和微血管募集。 将连续收集肌肉交感神经活动、心率、血压和通气量。 我们假设在缺氧条件下，微血管和动脉动力学将是不同的。 在这项初步研究中，我们将招募10名年龄在18-64岁之间的健康男性和女性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Hypoxia experienced environmentally or as a consequence of pathology causes changes in respiratory, cardiovascular, neural, and metabolic function. In patients with obstructive sleep apnea, a disease characterized by chronic hypoxia, cardiovascular and metabolic dysfunctions are reported, hypoxia has been implicated as the main factor. Cardiovascular control is mediated locally and centrally and is different along the vascular tree. Metabolic function is dependent on cellular activity and vascular dynamics. In the humans, hypoxia has been shown to cause glucose intolerance, an indicator of metabolic dysfunction. In rats, hyperinsulinemia caused microvascular recruitment that occurred without changes in arterial flow. Hypoxia, working via similar and different mechanisms as insulin could conceivably cause heterogeneous responses of the arteries and microvasculature leading to downstream metabolic dysfunction. To test the first part of this question we will evaluate both arterial blood flow and microvascular recruitment before and after hypoxia. Muscle sympathetic nerve activity, heart rate, blood pressure, and ventilation will be collected continuously. We hypothesize that under hypoxic conditions, microvascular and arterial dynamics will be different. For this initial study, we will recruit a total of 10 healthy men and women between the ages of 18-64 yrs.