GENERAL CLINICAL RESEARCH CENTER

超出提供的空间。 这项为期五年的竞争续期计划建议继续为Mallinckrodt GCRC提供资金 麻省总医院。临床研究中心为MGH提供了持续的支持 自1921年以来从事人体研究的研究人员，自1978年以来一直得到NCRR作为GCRC的支持。 在过去的5年里，GCRC支持了由200多名调查人员在 内科、神经科、精神科、儿科、骨科、麻醉科、放射科和 手术。目前的建议延续了玛嘉烈医院对临床研究的广泛支持， 包括119个方案，其中大部分(95%)由NIH支持的研究人员执行。建议数 研究包括新陈代谢、神经内分泌学、生殖生理学和 下丘脑-垂体-性腺轴，艾滋病毒，糖尿病，包括胰岛移植，精神疾病 包括精神分裂症、成瘾、强迫症和厌食症、神经性疾病等 如亨廷顿病、阿尔茨海默病和肌萎缩侧索硬化症，以及对神经系统的影响 全身麻醉，以及其他。除了已建立的生物营养学，生物统计和 生物信息学和临床实验室核心，我们提出了一种新的生物医学成像核心，该核心是 为了支持越来越多的MGH和MIT调查人员使用核磁共振、PET扫描和其他 人体研究中的成像模式。放射学、麻醉学、医学系26名研究人员的36项方案 将使用这一核心的医学、精神病学和神经病学也包括在内。一项正式的教育计划 调查人员、研究护士和营养师、医学和医学预科学生仍然是 当前应用程序。目前，9名CAP或K-23获奖者包括在赠款提案中。 位于麻省理工学院的一颗卫星GCRC，它已经越来越多地 在过去3年中纳入MGH GCRC活动的项目包括在本提案中。这个 卫星提案作为MGH的分包合同，包括48项协议，在其 麻省理工学院或两所GCRC的全部。MGH GCRC和MIT卫星之间的合作扩展 在GCRC的所有方面，包括联合管理，共享资源，如生物营养， 生物统计和成像核心，以及联合培训，以扩大两个机构和 为无缝连接提供便利

EXCEED THE SPACE PROVIDED. This five year competitive renewal proposes the continuing funding of the Mallinckrodt GCRC at Massachusetts General Hospital. The Clinical Research Center has provided continuous support for MGH investigators performing human research since 1921,with support from NCRR as a GCRC since 1978.In the previous 5 years, the GCRC has supported 190 protocols conducted by more than 200 investigators in the Departments of Medicine, Neurology, Psychiatry, Pediatrics, Orthopedics, Anesthesia, Radiology, and Surgery. The current proposal continues the wide-spread support for clinical investigation at the MGH, including 119 protocols with the majority (95%)performed by NIH supported investigators. The proposed studies include research in metabolism, neuroendocrinology, reproductive physiology and disorders of the hypothalamic-pituitary-gonadal axis, HIV, diabetes including islet transplantation, psychiatric disorders including schizophrenia, addiction, obsessive compulsive disorders and anorexia, neurologic disorders such as Huntington's disease, Alzheimer's disease and amyotrophic lateral sclerosis, and the neurologic effects of general anesthesia, among others. In addition to the established Bionutrition, Biostatistics and Bioinformatics, and Clinical Laboratory Cores, we propose a new Biomedical Imaging Core that is designed to support the increasing number of MGH and MIT investigators using NMR, PET scanning, and other imaging modalities in human research. Thirty six protocols from 26 investigators in Radiology,Anesthesia, Medicine, Psychiatry, and Neurology that will use this core are included. A formal program of education for investigators, research nurses and dietitians, medical and pre-med students remains a strong component of the current application. Currently, nine CAP or K-23 awardees are included in the grant proposal. A satellite GCRC, located at the Massachusetts Institute of Technology and which has been increasingly integrated into the MGH GCRC activities during the previous 3 years, is included in this proposal. The satellite proposal, structured as a subcontract to the MGH, includes 48 protocols that are conducted in their entirety at MIT or at both GCRCs. The collaboration between the MGH GCRC and MIT satellite extends across all aspects of the GCRC includingjoint administration, shared resources, such as the Bionutrition, Biostatistics, and Imaging Cores, and joint training to expand the research resources at both institutions and facilitate the seamless