INVESTIGATION OF WHITE MATTER INTEGRITY IN BIPOLAR DISORDER

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 虽然有证据表明双相情感障碍患者的大脑白色物质中存在高信号，但据我们所知，还没有对双相情感障碍中涉及情绪处理的白色物质连接区域进行调查。 在这项研究中，我们建议调查，通过使用扩散张量成像的双相情感障碍患者和健康对照组之间的可能的组差异，在水的自扩散的大脑白色物质束，和结构组的差异，在眼眶额叶和杏仁核。 据推测，与健康志愿者相比，患者的钩束各向异性分数较低，眼眶额叶N-乙酰-天冬氨酸含量较低，眼眶额叶和杏仁核结构改变。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. While there is evidence for signal hyperintensities in the brain white matter of individuals with bipolar disorder, to our knowledge there has been no investigation of the white matter connecting regions involved in emotional processing in bipolar disorder. In this study, we propose to investigate, through the use of diffusion tensor imaging possible group differences between patients with bipolar disorder and healthy controls in the water self-diffusion of brain white matter tracts, and structural group differences in the orbital frontal lobe and amydala. It is hypothesized that compared to healthy volunteers, patients will have lower fractional anisotropy in the uncinate fasciculus, lower orbital frontal N-acetyl-aspertate, and structural alterations in the orbital frontal lobe and amygdala.