ENHANCEMENT OF HUMORAL IMMUNE RESPONSES BY CD1D-RESTRICTED NKT CELLS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们准备了解B细胞和/或DCs的CD 1d表达是否是NKT增强的Ab应答所必需的。这是理解CD 1d限制性NKT细胞增强Ab应答机制的关键第一步。我们的发现将指导目标2的实验，并可能指导未来的疫苗策略。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are poised to understand if CD1d expression by B cells and/or DCs is required for NKT-enhanced Ab responses. This is a critical first step in understanding the mechanisms by which CD1d-restricted NKT cells enhance Ab responses. Our findings will direct the experiments in Aim 2 and may guide future vaccine strategies.