OVARIAN FAILURE

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 二聚体促卵泡素、激活素和卵泡抑素最初都被认为是调节促卵泡激素分泌的生殖内分泌激素。然而，在当前医学证据的重压下，这种模式已经扩大。激活素似乎在生殖和非生殖组织中发挥中央自分泌/旁分泌作用。抑制素和FS各自在激活素信号传导中具有重要的反调节功能。随着生殖年龄的增长，卵泡素B随卵泡池沿着下降，并干扰生殖年龄中期正常月经周期的动态。卵泡刺激素分泌抑制作用的丧失似乎是导致月经周期缩短和生育后期某些激素不可预测性的起始内分泌事件。它也可能与生殖老化中发生的生育率下降有关。在男性中，β-半胱氨酸B是性腺能力的一个很好的标志物，β-半胱氨酸B随年龄的下降反映了两性性腺储备的下降。循环激活素随着年龄的增长而增加，但其对女性和男性生殖的影响尚不清楚。FS似乎没有随着男性或女性的衰老而发生很大变化。在这个微妙平衡的调节三联体中，与年龄相关的波动影响生殖能力和实足衰老的后遗症。阐明负责这些激素的作用的分子途径可能会使其与当前衰老中的概念角色更紧密地结合起来。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Dimeric inhibins, activins, and follistatin (FS) were all initially characterized as reproductive endocrine hormones that regulate follicle-stimulating hormone (FSH) secretion. This model, however, has expanded under the weight of current medical evidence. Activin appears to play a central auto/paracrine role in reproductive and nonreproductive tissues. Inhibin and FS each have important counterregulatory functions in activin signaling. With reproductive aging, inhibin B declines along with the follicular pool and disturbs the dynamics of the normal menstrual cycle of midreproductive age. The loss of inhibin restraint of FSH secretion appears to be the initiating endocrine event that leads to menstrual cycle shortening and some of the hormonal unpredictability of the late reproductive years. It may also be related to the decline in fertility that occurs in reproductive aging. In men, inhibin B is an excellent marker for gonadal competence, and the decline of inhibin B with age reflects decreased gonadal reserve in both sexes. Circulating activin increases with aging, but its effect on reproduction in women and men is not clear. FS does not appear to change greatly with aging in men or women. The age-related fluctuations in this delicately balanced regulatory triad influence reproductive capacity and the sequelae of chronological aging. Elucidation of the molecular pathways responsible for the action of these hormones may allow closer integration with their current Conceptual roles in aging.