GENOME SCREEN FOR ASTHMA SEVERITY MODIFER POLYMORPHISMS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者的研究机构。 这项研究的目的是了解导致哮喘个体之间慢性哮喘严重程度差异的遗传变异。 在这个建议中，我们将产生一个列表中的20个自然发生的多态性变异哮喘相关基因确定的文献检索。 同时，我们将对1,500名哮喘儿童进行队列研究，这些儿童代表多个种族背景，男性和女性人数相等。 这些患者将进行基因分型和访谈，以评估慢性哮喘的严重程度，以及药物治疗，药物干预和环境暴露史。 然后将该“临床”数据与多态性数据相关联，以识别那些自然发生的变体，这些变体在控制药物治疗、医疗干预和环境暴露史的同时显示出与慢性哮喘严重程度的统计学显著相关性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the proposed study is to understand the genetic variation leading to differences in chronic asthma severity between asthmatic individuals. In this proposal we will generate a list of 20 naturally occurring polymorphic variants in asthma-associated genes determined by a literature search. In parallel, we will conduct a cohort study of 1,500 asthmatic children representative of multiple ethnic backgrounds, with equal numbers of males and females. These patients will be genotyped and interviewed to assess chronic asthma severity, as well as medication, medication intervention, and environmental exposure history. This "clinical" data will then be correlated with the polymorphism data to identify those naturally occurring variants, which show a statistically significant association with chronic asthma severity while controlling for medication, medical intervention, and environmental exposure history.