Older Americans Independence Center

描述(由申请人提供)：该提案旨在约翰·霍普金斯医疗机构建立一个老年美国人独立中心。该中心的重点是通过制定干预措施来促进虚弱老年人的独立性，以预防或改善虚弱老年人面临的许多严重、不利的后果。为了实现这一点，一个由高级和初级调查人员组成的多学科小组，在这个机构的多个部门和项目中，提议通过这个OAIC实施：1.领导小组，将刺激、领导和维持全大学范围内调查脆弱、其病因和治疗机会的跨学科研究计划；2.对于创建下一代关于老年人脆弱的研究至关重要的基础设施和方法发展；3.支持杰出的初级教员的职业发展，他们致力于将导致脆弱的治疗和预防的研究事业；以及4.培育和支持先导性研究，为研究者发起和资助的长期脆弱性研究提供基础。伊斯兰会议组织将提供至关重要的支助，以便将该机构已有的强大力量整合为一项统一而有力的努力，以制定针对脆弱性的干预措施。它旨在确保基础研究和临床/人群研究之间的多学科转化，并将两者转化为治疗虚弱的方法。这种有组织的基础设施和科学领导力可以作为建议和合作的来源，为我们自己机构和其他机构的研究人员提供关于衰老脆弱的研究。OAIC将由约翰·霍普金斯老龄化与健康中心领导和管理，所有致力于老龄研究的机构项目都将强有力地领导和参与；它还将吸收以前没有参与脆弱性研究但通过本提案的规划过程致力于这项工作的领导人和调查人员。该OAIC具有强大的机构承诺，基于医疗机构统一和加强老龄化研究的优先事项，并突出其对整个机构的重要性。总体而言，它旨在带头进行新的深度和强度的研究，以改善结果并促进虚弱的老年人的独立性。

DESCRIPTION (provided by applicant): This proposal seeks to establish an Older Americans Independence Center at the Johns Hopkins Medical Institutions. The focus of this center is to promote independence for frail older adults through the development of interventions to prevent or ameliorate frailty and the many serious, adverse outcomes that frail older adults are at risk for. To accomplish this, a multidisciplinary group of senior and junior investigators, in multiple Departments and Programs at this institution, propose to implement, through this OAIC, 1. the leadership group that will stimulate, lead and sustain a University-wide interdisciplinary research program investigating frailty, its etiology and opportunities for treatment; 2. the infrastructure and methodologic development essential to creating the next generations of research on frailty in older adults; 3. to support the career development of outstanding junior faculty committed to research careers that will lead to treatments for frailty and its prevention; and 4. to cultivate and support pilot studies that will provide the basis for investigator-initiated and funded research on frailty over the long run. The OAIC would provide the support critical to organizing the substantial strengths already at this institution into a unified and potent effort directed at developing interventions for frailty. It is designed to ensure multidisciplinary translation between basic and clinical/population-based research, and of both into development of treatments for frailty. This organized infrastructure and scientific leadership can serve as a source of advice and collaborations to investigators at our own institution and at other institutions in the area of research on frailty in aging. The OAIC will be administratively led by, and housed in, the Johns Hopkins Center on Aging and Health, with strong leadership and participation by all of the institutional programs committed to aging research; it will also incorporate leaders and investigators not previously involved in research on frailty but who have made a commitment to this work through the planning process for this proposal. This OAIC has strong institutional commitment, based on the priority at the Medical Institutions for the unification and strengthening of aging research and spotlighting its importance for the entire institution. Overall, it is designed to spearhead a new depth and intensity of research to improve outcomes and promote independence for frail, older adults.