REUSABLE STORAGE PHOSPHOR FOR ADVANCED RADIATION THERAPY DOSIMETRY

描述(申请人提供)：用于放射治疗剂量测定的可重复使用的存储荧光粉。摘要近十年来，随着成像技术和适形剂量传递技术的发展，现代放射治疗取得了长足的进步。随着治疗计划和剂量传递的复杂性的增加，对多维定量剂量传递验证的需求不断增长。射线胶片已成为二维剂量分布测量的事实标准。随着诊所转向电子成像，对射线照相胶片使用至关重要的胶片冲洗机正在被拆除。多点电子剂量计最近被引入，并被用于剂量分布验证。虽然这些设备的使用快速方便，但它们仅限于测量垂直于入射光束的单个平面，不能用于大多数几何模型，而几何模型的使用对治疗计划系统的调试至关重要。除了测量维度之外，剂量计的一个重要操作特征是用户表征和监控剂量计响应的能力。多点电子剂量计可以做到这一点，但更高分辨率的一次性剂量计，如射线照相或放射变色胶片，则无法做到这一点。我们建议开发一种新型的、可重复使用的、高分辨率的二维剂量计，其有效原子序数(Z)接近水。该剂量计将是由分散在聚合物粘结剂中的低Z存储磷光颗粒组成的存储磷光板(SPP)。我们的第一个目标是开发一种制备低Z储存荧光粉的工艺。我们的第二个目标是量化剂量学特性，并优化目标1中开发的荧光粉生产工艺。我们的第三个目标是使用最先进的流延方法生产SPP原型。这些特定目标的成功完成将提供一种定量的二维剂量计，它可以在现有的几何模型中使用，并且可以重复使用，以便物理学家可以确定和监测剂量学特性。

DESCRIPTION (provided by applicant): Reusable storage phosphor for radiation therapy dosimetry. Abstract Modern radiation therapy has advanced considerably in the last decade with the development of improved imaging and conformal dose delivery techniques. With the subsequent increased complexity of treatment planning and dose delivery, there has been growing demand for multi-dimensional quantitative dose delivery validation. Radiographic film has become the de facto standard for two-dimensional dose distribution measurements. As clinics move towards electronic imaging, the film processors that are critical for radiographic film use are being removed. Multi-point electronic dosimeters have recently been introduced and are being used for dose distribution validation. While the use of these devices is fast and convenient, they are limited to measuring single planes oriented normal to the incident beams and cannot be used in most geometric phantoms, the use of which are critical to treatment planning system commissioning. In addition to the measurement dimensionality, an important operating characteristic for dosimeters is the user's ability to characterize and monitor the dosimeter response. This has been possible with multipoint electronic dosimeters, but not higher-resolution single-use dosimeters such as radiographic or radiochromic film. We propose to develop a novel, reusable, high-resolution two-dimensional dosimeter with an effective atomic number (Z) close to water. This dosimeter will be a storage phosphor plate (SPP) consisting of low Z storage phosphor particles dispersed in a polymer binder. Our first aim is to develop a process for preparing low Z storage phosphor powders. Our second aim is to quantify the dosimetric properties and optimize the phosphor production process developed in aim 1. Our third aim is to produce a prototype SPP using a state-of-the-art tape-casting method. The successful completion of these specific aims will provide a quantitative two-dimensional dosimeter that can be used in existing geometric phantoms and that can be reused so that the dosimetry characteristics can be determined and monitored by the physicist.