Motion-immune magnetic resonace imaging

描述（由申请人提供）：拟议项目的长期目标是通过消除运动伪影来提高磁共振成像（MRI）期间的图像质量。MRI在扫描过程中极易受到运动的影响，运动诱发伪影的消除将基于对成像身体的实时运动跟踪，并应用跟踪数据重新对齐MRI扫描仪的梯度，以补偿运动。这项新技术可以对医疗保健系统产生重大影响，因为在进行的研究中，大约20%的运动伪影会降低图像质量，并且通常需要重复研究。此外，新的MRI模式，如功能性和弥散性MRI，受到运动的严重影响，消除运动伪影将促进其临床应用。在项目一期的可行性论证之后，我们将继续进入二期。该项目的具体目标包括：A-将fda批准的用于MRI引导手术干预的EndoScout跟踪系统修改为可与主要类型的诊断性MRI扫描仪接口的运动跟踪系统；B -利用跟踪系统提供的运动信息，通过梯度重新对准将感兴趣的常规扫描序列修改为运动免疫序列；C -验证基于运动跟踪的梯度重对准运动补偿可以提高研究和临床MRI图像质量的假设，并且优于目前使用的消除运动伪影的方法。该技术将由Robin Medical， Inc.和马萨诸塞州总医院合作开发：Robin Medical将开发新一代EndoScout跟踪系统，该系统可以成为诊断MRI扫描仪的标准组件；麻省总医院的Van der Kouwe博士将修改该系统人体测试所需的各种研究和临床扫描序列。通过移动幻影的技术测试成功地证明了运动伪影的缓解，该系统将在志愿者身上进行测试，并通过正在进行的研究和临床MRI人体研究进行测试。公共卫生相关性：拟议的运动伪影缓解技术可以降低与重复MRI扫描相关的医疗成本，这些扫描通常需要患者运动。此外，由于MRI的高成本，许多诊断性MRI扫描由于运动而降级，而不能重复，因此新技术可以通过提供更高质量的图像来提高MRI的诊断率。此外，运动免疫序列可用于儿科患者，并减少该人群中某些年龄组麻醉的需要。

DESCRIPTION (provided by applicant): The long term aims of the proposed project are to improve image quality during magnetic resonance imaging (MRI) by elimination of motion artifacts. MRI is highly susceptible to motion during scan, and the elimination of the motion-induced artifacts will be based on real-time motion tracking of the imaged body and the application of the tracking data to re-align the gradients of the MRI scanner, in order to compensate for motion. This new technology can have significant impact on the health care system as motion artifacts degrade image quality in about 20% of performed studies and often require repetition of the study. Furthermore, new MRI modalities like functional and diffusion MRI are severely affected by motion, and the elimination of motion artifacts will facilitate their clinical use. Following feasibility demonstration during Phase I of the project, we continue into Phase II. The specific aims of the project include: A - To modify the FDA-cleared EndoScout tracking system that is clinically used in MRI-guided surgical interventions into a motion tracking system that can be interfaced with major types of diagnostic MRI scanners; B - To modify routine scan sequences of interest into motion-immune sequences by gradient re-alignment using motion information supplied by the tracking system; C - To test the hypothesis that motion compensation through gradient re-alignment based on motion tracking can improve image quality in research and clinical MRI and is superior to currently used methods for motion artifact elimination. The technology will be developed through a collaboration between Robin Medical, Inc., and the Massachusetts General Hospital: Robin Medical will develop a new generation of the EndoScout tracking system that can become a standard components on diagnostic MRI scanners; Dr. Van der Kouwe at the Massachusetts General Hospital will modify various research and clinical scan sequences that will be needed during human tests of the system. Following the demonstration of successful motion artifact mitigation through technical testing with moving phantom, the system will be tested on volunteers and through on going research and clinical MRI human studies. PUBLIC HEALTH RELEVANCE: The proposed motion artifact mitigation technology may reduce healthcare costs associated with the common need to repeat MRI scans that are compromised by patient motion. In addition, as many diagnostic MRI scans are degraded by motion but not repeated due to the high cost of MRI, the new technology can improve the diagnostic yield of MRI by providing higher quality images. Furthermore, the motion-immune sequences may be used with pediatric patients and reduce the need for anesthesia in some age groups of this population.