Modelling epigenomic change during early breast carcinogenesis using in vitro and in vivo model systems

表观遗传学描述了基因如何在不改变DNA序列的情况下被打开和关闭。表观遗传学变化很常见，通常发生在癌症的早期，但我们不知道表观遗传学变化在癌症中发生在哪里或如何发生。在这项提案中，我们将创建正常和癌症乳腺细胞表观遗传景观的第一个详细地图。这些图谱将使我们能够预测乳腺癌中表观遗传病变发生的位置，这将对癌症治疗具有重要的诊断和治疗价值。

Epigenetics describes how genes can be turned on and off without a change in the DNA sequence. Epigenetic changes are common and often occur early in cancer, but we do not know where or how epigenetic changes occur in cancer. In this proposal we will create the first detailed map of the epigenetic landscape of normal and cancer breast cells. These maps will allow us to predict where epigenetic lesions occur in breast cancer, which will have important diagnostic and therapeutic value for cancer treatments.