BETA CELL PHYSIOLOGY & BIOCHEMISTY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 线粒体在胰岛细胞胰岛素分泌的调节中起着关键作用，而对燃料促分泌剂的反应耗氧量是线粒体代谢的重要标志。振荡代谢，包括耗氧量的振荡，被认为突出了β细胞的脉动胰岛素输出。在2型糖尿病患者中，胰岛素分泌的振荡是重要的，这一点从它的丢失中得到了提示。目前，通过磷酸果糖激肽(PFK)的振荡糖酵解(PFK)被认为是产生振荡胰岛素分泌的主要系统。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Mitochondria play a key role in the regulation of insulin secretion from pancreatic islet cells, and oxygen consumption in response to fuel secretagogues represents an important marker of mitochondrial metabolism. Oscillatory metabolism, including oscillations in oxygen consumption, is believed to underline pulsatile insulin output from the beta cells. Oscillatory insulin secretion is important, as suggested by its loss in type 2 diabetic patients. Currently, oscillatory glycolysis via phosphofructokinas (PFK) has been considered the main system responsible for generation of oscillatory insulin secretion.