C ALPHA CHAIN TRACE BASED ON CRYOEM MAPS

这个子项目是众多研究子项目之一

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We aim to develop a novel framework for semi- to fully- automated model building from a cryoEM map at intermediate resolution. This methodology is based on computing a simplified, geometric representation of the cryoEM map, known as the skeleton. The geometry and topology of the skeleton reflect important shape and connectivity information of the density map, which in turn enables the possibility of automating the identification of secondary structure elements and building of pseudo-atomic protein models within one coherent framework.